| 杨晶,丁里,张蕾,杨淑,符浩.不同年龄健康成人大脑皮层厚度差异[J].中国医学影像技术,2022,38(6):825~830 |
| 不同年龄健康成人大脑皮层厚度差异 |
| Differences of cerebral cortex thickness in healthy adults with different ages |
| 投稿时间：2021-09-24 修订日期：2022-03-04 |
| DOI：10.13929/j.issn.1003-3289.2022.06.007 |
| 中文关键词: 大脑皮层 磁共振成像 年龄 大脑皮层厚度 |
| 英文关键词:cerebral cortex magnetic resonance imaging age brain cortical thickness |
| 基金项目: |
|
| 摘要点击次数: 1434 |
| 全文下载次数: 334 |
| 中文摘要: |
| 目的 观察不同年龄健康成人大脑皮层厚度的差异。方法 对134名健康成人，包括青年组（18~44岁）54名、中年组（45~59岁）40名及老年组（≥60岁）40名采集脑结构MR T1WI。采用FreeSurfer 6.0软件对图像进行基于表面的形态测量学分析，观察左、右侧大脑皮层厚度与年龄的相关性；比较3组间左、右侧大脑皮层厚度的差异，并对组间皮层厚度存在差异的脑区进行图形可视化。结果 左、右侧大脑皮层厚度均随年龄增长而下降（r=－0.57、－0.52，P均<0.01）。3组间左、右侧大脑皮层厚度总体差异有统计学意义（F=70.20，P<0.01），两两比较差异均有统计学意义（P均<0.01）。中年组20个脑区团簇皮层厚度较青年组变薄，老年组7个脑区团簇皮层厚度较中年组变薄，老年组29个脑区团簇皮层厚度较青年组变薄。结论 健康成人大脑皮层厚度随年龄增长而变薄。 |
| 英文摘要: |
| Objective To observe the difference of cerebral cortex thickness in healthy adults with different ages. Methods Brain MR T1WI were acquired in 134 different aged healthy adults, including 54 subjects in youth group (18-44 years), 40 in middle age group (45-59 years) and 40 in old age group (≥ 60 years). Surface based morphometry was performed on images of all subjects using FreeSurfer 6.0 software. The correlation between age and cortical thickness of left and right cerebral cortex was observed. The thicknesses of left and right cerebral cortex were compared among 3 groups, and the differences of cerebral cortex thickness were visualized. Results The left and right cortical thicknesses decreased with aging (r=-0.57, -0.52, both P<0.01). There were statistical differences of the thicknesses of left and right cerebral cortex among 3 groups (F=70.20, P<0.01) and between each 2 groups (all P<0.01). Thinned cortical thicknesses were found in 20 clusters of middle age group compared with those of youth group, in 7 clusters of old age group compared with those of middle age group, while in 29 clusters of old age group compared with those of youth group. Conclusion The cerebral cortex thickness of healthy adults decreased with aging. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
