| 冯晓蕾,黄丽丽,周琦,李苗.2型糖尿病患者骨骼肌厚度和弹性变化及其影响因素[J].中国医学影像技术,2024,40(2):270~274 |
| 2型糖尿病患者骨骼肌厚度和弹性变化及其影响因素 |
| Changes of thickness and elasticity of skeletal muscles in diabetic patients and relative impact factors |
| 投稿时间：2023-10-23 修订日期：2023-12-04 |
| DOI：10.13929/j.issn.1003-3289.2024.02.024 |
| 中文关键词: 糖尿病,2型 肌,骨骼 弹性成像技术 前瞻性研究 |
| 英文关键词:diabetes mellitus, type 2 muscle, skeletal elasticity imaging techniques prospective studies |
| 基金项目:西安交通大学第二附属医院人才培养专项科研基金[RC（GG）202005）]。 |
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| 中文摘要: |
| 目的 观察2型糖尿病患者骨骼肌厚度和弹性变化及其影响因素。方法 前瞻性招募62例2型糖尿病患者（T2DM组）及60名健康成年人（HC组），以剪切波弹性成像（SWE）技术检测其放松及收缩状态下腹直肌和腓肠肌最大杨氏模量（Emax），比较组间2种状态下骨骼肌厚度及弹性模量，并采用多重线性回归分析影响腹直肌和腓肠肌弹性模量的因素。结果 组间放松及收缩状态下腹直肌和腓肠肌厚度差异均无统计学意义（P均>0.05）；T2DM组放松及收缩状态下腹直肌及腓肠肌Emax均低于HC组（P均<0.05）。多重线性回归分析显示，T2DM组放松及收缩状态下腹直肌及腓肠肌弹性模量均随病程、空腹血糖（FBG）及糖化血红蛋白（HbA1c）而呈线性降低（P均<0.05）。结论 2型糖尿病患者骨骼肌弹性模量降低，且随病程、FBG及HbA1c而呈线性下降。 |
| 英文摘要: |
| Objective To observe changes of thickness and elasticity of skeletal muscles in patients with type 2 diabetes mellitus (T2DM) and relative impact factors. Methods Totally 62 T2DM patients (T2DM group) and 60 healthy adults (HC group) were prospectively recruited. Shear wave elastography (SWE) technology was used to measure the maximum Young's modulus (Emax) of the rectus abdominis and gastrocnemius muscles under relaxed and contracted states in both groups. The thickness and elasticity modulus of the skeletal muscles under the two states were compared between groups. Multiple linear regression analysis was performed to screen impact factors of the elasticity modulus of the rectus abdominis and gastrocnemius muscles. Results No significant difference of muscle thicknesses of rectus abdominis, nor of gastrocnemius muscle was found between groups under relaxed and contracted states (all P>0.05). Under both relaxed and contracted states, the Emax of the rectus abdominis and gastrocnemius muscle in T2DM group were all lower than those in HC group (all P<0.05). Multiple linear regression analysis showed that in T2DM group, the elasticity modulus of the rectus abdominis and gastrocnemius muscle under both relaxed and contracted states decreased linearly with disease duration, fasting blood glucose (FBG) and glycosylated hemoglobin (HbA1c) (all P<0.05). Conclusion The elasticity modulus of skeletal muscle decreased in T2DM patients, and the reducing scales linearly related to disease duration, FBG and HbA1c. |
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