| 徐春阳,詹松华,谭文莉,赵磊,张钰莹,孔营楠,杨玉婵.MRI观察无先兆偏头痛患者大脑活动异常[J].中国医学影像技术,2024,40(1):112~115 |
| MRI观察无先兆偏头痛患者大脑活动异常 |
| MRI observation on abnormal brain activity in patients with migraine without aura |
| 投稿时间：2023-07-04 修订日期：2023-09-24 |
| DOI：10.13929/j.issn.1003-3289.2024.01.022 |
| 中文关键词: 无先兆偏头痛 局部一致性 磁共振成像 |
| 英文关键词:migraine without aura regional homogeneity magnetic resonance imaging |
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| 中文摘要: |
| 目的 以MRI观察无先兆偏头痛（MowA）患者大脑异常活动。方法 前瞻性纳入50例MwoA患者（MwoA组）及46名健康志愿者（对照组），以功能MRI（fMRI）观察其脑区动态局部一致性（dReHo）；提取组间dReHo值存在差异脑区，与临床量表行相关性分析。结果 相比对照组，MwoA组双侧距状裂周围皮层、右枕中回dReHo值增高，右颞中回、右额中回、左楔叶dReHo值减低（GRF校正，体素水平P均<0.005，簇水平P均<0.05）；权重分析显示，权重绝对值排名前3位脑区分别为右距状裂周围皮层、左楔叶及右枕中回。MwoA患者左距状裂周围皮层dReHo值与抑郁自评量表（SDS）呈负相关（r=-0.28，P=0.04）。结论 MwoA患者视觉信息上行传递通路存在异常，特别是右距状裂周围皮层、左楔叶及右枕中回。 |
| 英文摘要: |
| Objective To observe the abnormal brain activity in patients with migraine without aura (MwoA) with MRI. Methods Fifty MwoA patients (MwoA group) and 46 healthy volunteers (control group) were prospectively enrolled. Functional MRI (fMRI) was performed to observe the dynamic regional homogeneity (dReHo) of brain regions, then brain regions with differences of dReHo value between groups were extracted, and correlations with clinical scales were analyzed. Results Compared with control group, dReHo values of surrounding cortex of bilateral calcarine fissure and right middle occipital gyrus increased, of right middle temporal gyrus, right middle frontal gyrus and left cuneus decreased in MwoA group (GRF correction, voxel level all P<0.005, cluster level all P<0.05). The weight analysis showed that brain regions with top 3 absolute weight values were surrounding cortex of right calcarine fissure, left cuneus and right middle occipital gyrus. dReHo value of surrounding cortex of left calcarine fissure in MwoA patients was negative correlated with self-rating depression scale (SDS) (r=-0.28, P=0.04). Conclusion Abnormalities in the upward transmission pathway of visual information existed in MwoA patient, especially in surrounding cortex of right calcarine fissure, left cuneus and right middle occipital gyrus. |
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