| 林晨琳,张帆,李猛城,付莹,刘颖.多参数MRI随访观察遗传性痉挛性截瘫5型患者脊髓微结构改变[J].中国医学影像技术,2024,40(1):14~21 |
| 多参数MRI随访观察遗传性痉挛性截瘫5型患者脊髓微结构改变 |
| Multiparameter MRI for follow-up observation on changes of spinal cord microstructures in patients with hereditary spastic paraplegias type 5 |
| 投稿时间：2023-07-27 修订日期：2023-10-05 |
| DOI：10.13929/j.issn.1003-3289.2024.01.003 |
| 中文关键词: 痉挛性截瘫,遗传性 脊髓 磁共振成像 |
| 英文关键词:spastic paraplegia, hereditary spinal cord magnetic resonance imaging |
| 基金项目:福建省科技创新联合资金项目（2021Y9097）、福建省自然科学基金（2022J05142）。 |
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| 中文摘要: |
| 目的 评估多参数MRI随访观察遗传性痉挛性截瘫5型（SPG5）患者脊髓微结构改变的价值。方法 前瞻性纳入11例接受颈胸段脊髓MR检查及痉挛性截瘫评价量表（SPRS）评分的SPG5患者，随访1年后进行第2次MR检查及SPRS评分，比较2次SPRS评分、脊髓整体结构及脊髓微结构变化。结果 11例SPG5患者2次SPRS评分结果差异无统计学意义（P>0.05）。相比首次颈胸段脊髓MRI，第2次MRI显示脊髓萎缩程度加重；首次与第2次MRI所测C4右侧皮质脊髓束（CST）轴向弥散系数（AD）差异有统计学意义（t=3.987，P<0.01），C4其余参数差异均无统计学意义（P均>0.05）；其余椎体脊髓白质、后索、左/右侧CST的各向异性分数（FA）、平均弥散系数（MD）、AD、径向弥散系数（RD）及T1值，以及C1~T9椎体截面积（CSA）、左右径及前后径差异均无统计学意义（P均>0.05）。第2次MRI显示颈段脊髓白质、后索及CST的FA均低于、而RD均高于首次（P均>0.05）。结论 多参数MRI可用于随访观察SPG5患者脊髓微结构变化。 |
| 英文摘要: |
| Objective To explore the value of multiparameter MRI for follow-up observation on changes of spinal cord microstructures in patients with hereditary spastic paraplegias type 5. Methods Eleven patients with SPG5 who underwent cervico-thoracic spinal cord MR examination and spastic paraplegia rating scale (SPRS) were prospectively enrolled. The second MR examination and SPRS were completed after 1 year follow-up, and the changes of SPRS score, the overall structures and microstructures of spinal cord were compared. Results No significant difference of SPRS scores was found (P>0.05). Compared to the first cervico-thoracic spinal cord MR examination, atrophy of spinal cord aggravated in the second time MRI. Significant difference of axial diffusivity of C4 right corticospinal tract (CST) was found (t=3.987, P<0.01), but not of the other parameters of C4 (all P>0.05) between the first and the second time MRI. No significant difference of fractional anisotropy (FA), mean diffusivity (MD), AD, radial diffusivity (RD) nor T1 value of the other centrums' white matter, posterior funiculus or bilateral CST in spinal cord was found between the first and the second time MRI (all P>0.05). Meanwhile, no significant difference of CSA, left and right diameter nor anteroposterior diameter of C1-T9 was found between the first and second time MRI (all P>0.05). FA value of white matter, posterior funiculus and bilateral corticospinal tract in cervical spinal cord were all lower, whereas RD value at the above position were all higher in the second time MRI than those in the first time MRI (all P>0.05). Conclusion Multiparameter MRI could be used for follow-up observation on changes of microstructure spinal cord in patients with hereditary spastic paraplegias type 5. |
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