刘亚超,刘家金,张晓军,王旻姝,董彦良,殷小涛,施彦坤,周晖,徐白萱,高江平.18F-DCFPyL PET/CT显像对前列腺根治性切除术患者有无区域淋巴结转移的诊断价值[J].中国医学影像技术,2020,36(6):
18F-DCFPyL PET/CT显像对前列腺根治性切除术患者有无区域淋巴结转移的诊断价值
The value of 18F-DCFPyL PET/CT imaging in the diagnosis of regional lymph node metastasis in patients with radical prostatectomy
投稿时间:2019-08-20  修订日期:2020-06-14
DOI:
中文关键词:  前列腺癌  PET/CT  PSMA  前列腺根治性切除术  淋巴结清扫术
英文关键词:prostate cancer  PET/CT  PSMA  Radical prostatectomy  lymphadenectomy
基金项目:前列腺癌早期诊断的PET/MR多模态分子影像研究,国家自然科学基金项目(面上项目),项目批准号: 81571715
作者单位E-mail
刘亚超 中国人民解放军总医院 yachao301@163.com 
刘家金 中国人民解放军总医院  
张晓军 中国人民解放军总医院  
王旻姝 中国人民解放军总医院  
董彦良 中国人民解放军总医院  
殷小涛 中国人民解放军总医院  
施彦坤 中国人民解放军总医院  
周晖 中国人民解放军总医院  
徐白萱* 中国人民解放军总医院 xbx301@163.com 
高江平 中国人民解放军总医院  
摘要点击次数: 1366
全文下载次数: 644
中文摘要:
      目的:探讨18F-DCFPyL PET/CT显像对前列腺根治性切除术患者有无区域淋巴结转移的诊断价值。 方法:回顾性分析在我院同时行前列腺根治性切除术及盆腔淋巴结清扫术的49例前列腺癌患者术前的18F-DCFPyL PET/CT图像及其临床资料。统计清扫淋巴结的总数及转移淋巴结情况,计算18F-DCFPyL PET/CT对区域转移淋巴结的诊断效能。利用独立样本t检验检测切除后的转移淋巴结及非转移淋巴结长径、中径及短径差异是否具有统计学意义。 结果:49例患者共清扫淋巴结511枚,其中10例患者共出现14枚淋巴结转移,18F-DCFPyL PET/CT正确诊断出其中的9例共12枚转移淋巴结。切除后的转移淋巴结组及非转移淋巴结组的长径、中径及短径的均值分别为1.64±1.23 cm VS 1.12±0.61 cm、1.05±0.87 cm VS 0.59±0.39 cm、0.61±0.54 cm VS 0.36±0.19 cm,差异均无统计学意义(P值均大于0.05)。18F-DCFPyL PET/CT诊断前列腺癌根治性切除患者有无淋巴结转移的灵敏度为90.00%,特异性为100%,准确性为97.96%,阳性预测值为100%,阴性预测值为97.50%。 结论:前列腺癌区域淋巴结是否转移与其大小无关,18F-DCFPyL PET/CT对于前列腺癌区域淋巴结的良恶性鉴别具有较高的诊断价值,有望用于指导前列腺根治性切除术时是否需要清扫区域淋巴结及其合理的清扫范围。
英文摘要:
      Objective: To evaluate the value of 18F-DCFPyL PET/CT in the diagnosis of regional lymph node metastasis in patients with radical prostatectomy. Methods: Retrospective analysis of the preoperative 18F-DCFPyL PET/CT images and clinical data of 49 patients with prostate cancer who underwent radical prostatectomy and pelvic lymph node dissection simultaneously in our hospital. The total number of dissected lymph nodes and metastatic lymph nodes were counted, and the diagnostic efficacy of 18F-DCFPyL PET/CT for regional metastatic lymph nodes was calculated. Independent sample t test was used to detect whether the differences in the long diameter, middle diameter and short diameter metastatic lymph nodes and non-metastatic lymph nodes after resection were statistically significant. Results: A total of 511 lymph nodes were dissected in 49 patients, and a total of 14 lymph node metastases were found in 10 patients, 9 of which were correctly diagnosed by 18F-DCFPyL PET/CT. The mean long diameter, medium diameter and short diameter of metastatic and non-metastatic lymph nodes after resection were 1.64±1.23cm VS 1.12±0.61cm, 1.05±0.87cm VS 0.59±0.39cm, 0.61±0.54cm VS 0.36±0.19cm, with no statistical significance (all P values were greater than 0.05). The sensitivity, specificity and accuracy of 18F-DCFPyL PET/CT in the diagnosis of lymph node metastasis in patients with radical resection of prostate cancer were 90.00%, 100% and 97.96%, respectively. The positive predictive value was 100% and the negative predictive value was 97.50%. Conclusion: Regional lymph node metastasis of prostate cancer is independent of its size. 18F-DCFPyL PET/CT has a high diagnostic value for the benign and malignant differentiation of regional lymph node in prostate cancer, and is expected to be used to guide whether regional lymph node dissection is needed and its reasonable range of dissection during radical prostatectomy.
查看全文  查看/发表评论  下载PDF阅读器