张丽,李兵,文哲,童冠圣.不同病理分级腹膜假黏液瘤:18F-FDG PET/CT双时相显像表现及血清肿瘤标志物水平[J].中国医学影像技术,2024,40(6):880~884
不同病理分级腹膜假黏液瘤:18F-FDG PET/CT双时相显像表现及血清肿瘤标志物水平
Pseudomyxoma peritonei: 18F-FDG PET/CT dual-phase imaging and serum tumor markers among different pathological grades
投稿时间:2024-01-09  修订日期:2024-02-14
DOI:10.13929/j.issn.1003-3289.2024.06.017
中文关键词:  假黏液瘤,腹膜  正电子发射断层显像术  肿瘤标记,生物学
英文关键词:pseudomyxoma peritonei  positron-emission tomography  tumor markers, biological
基金项目:
作者单位E-mail
张丽 首都医科大学附属北京世纪坛医院核医学科, 北京 100038  
李兵 清华大学附属北京清华长庚医院肿瘤外科, 北京 102218  
文哲 首都医科大学附属北京世纪坛医院核医学科, 北京 100038  
童冠圣 首都医科大学附属北京世纪坛医院核医学科, 北京 100038 tgseng@163.com 
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中文摘要:
      目的 对比不同病理分级腹膜假黏液瘤(PMP)18F-FDG PET/CT双时相显像表现及血清肿瘤标志物水平。方法 回顾性分析31例经病理确诊阑尾来源PMP患者,根据病理结果分为低级别、高级别及高级别伴印戒细胞PMP。对比不同级别PMP 18F-FDG PET/CT常规和延迟显像表现,以及PET/CT检查前1个月内血清癌胚抗原(CEA)、糖类抗原(CA) 125及CA 19-9水平。结果 31例PMP包括14例低级别、12例高级别及5例高级别伴印戒细胞PMP。18F-FDG PET/CT延迟显像中,低、高级别PMP病灶最大标准摄取值(SUVmax)、病灶SUVmax与肝脏平均标准摄取值之比(SUVmax/SUVliver mean)及PET-腹膜癌指数(PCI)均高于常规18F-FDG PET/CT显像(P均<0.05);延迟显像中,高级别伴印戒细胞PMP病灶SUVmax、SUVmax/SUVliver mean和PET-PCI均与常规显像差异均无统计学意义(P均>0.05)。不同病理分级PMP患者之间,CEA、CA 125及CA 19-9水平差异均无统计学意义(P均>0.05)。结论 不同病理分级PMP的18F-FDG PET/CT双时相显像表现具有一定特征性,血清肿瘤标志物水平与PMP病理分级无明显相关。
英文摘要:
      Objective To investigate 18F-FDG PET/CT dual-phase imaging features and serum tumor marker levels of pseudomyxoma peritonei (PMP) with different pathological grades. Methods A total of 31 patients with pathologically confirmed PMP originated from appendix were retrospectively analyzed. The tumors were divided into low-grade, high-grade and high-grade with signet-ring cell PMP according to pathological results. 18F-FDG PET/CT conventional and delayed imaging manifestations, as well as serum levels of carcinoembryonic antigen (CEA), carbohydrate antigen (CA) 125 and CA 19-9 within 1 month before PET/CT examination were comparatively analyzed among PMP with different pathological grades. Results Among 31 cases, low-grade PMP was found in 14 cases, high-grade PMP in 12 cases while high-grade with signet-ring cell PMP was detected in 5 cases. The maximal standard uptake value (SUVmax) of PMP lesion, the ratio of SUVmax to mean standard uptake value for the liver (SUVmax/SUVliver mean) and PET-peritoneal cancer index (PCI) of low- and high-grade PMP measured on delayed imaging were all higher than those measured on conventional imaging (all P<0.05). SUVmax, SUVmax/SUVliver mean and PET-PCI of high-grade with sig-ring cell PMP lightly increased on delayed imaging compared with those on conventional imaging, but no significant difference was not (all P>0.05). No statistical difference of serum CEA, CA 125 and CA 19-9 levels was observed among PMP with different pathological grades. Conclusion 18F-FDG PET/CT dual-phase imaging manifestations of different pathological grades PMP had certain characteristics, while no significant correlation was found between serum tumor marker level and pathological grade of PMP.
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