王海阔,张杰,张耀武,郑广浩,李俊杰,王永志,贾文清.脊髓H3K27M突变型与野生型星形细胞分化弥漫性中线胶质瘤MRI特征[J].中国医学影像技术,2024,40(6):815~819
脊髓H3K27M突变型与野生型星形细胞分化弥漫性中线胶质瘤MRI特征
MRI features of H3K27M mutant type and wild type astrocyte differentiated diffuse midline glioma in spinal cord
投稿时间:2024-03-21  修订日期:2024-05-13
DOI:10.13929/j.issn.1003-3289.2024.06.005
中文关键词:  脊髓  胶质瘤  突变  磁共振成像
英文关键词:spinal cord  glioma  mutation  magnetic resonance imaging
基金项目:
作者单位E-mail
王海阔 首都医科大学附属北京天坛医院放射科, 北京 100070  
张杰 首都医科大学附属北京天坛医院放射科, 北京 100070  
张耀武 首都医科大学附属北京天坛医院神经外科, 北京 100070  
郑广浩 首都医科大学附属北京天坛医院神经外科, 北京 100070  
李俊杰 首都医科大学附属北京天坛医院放射科, 北京 100070  
王永志 首都医科大学附属北京天坛医院神经外科, 北京 100070  
贾文清 首都医科大学附属北京天坛医院神经外科, 北京 100070 coffeemd@vip.163.com 
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中文摘要:
      目的 观察脊髓H3K27M突变型与野生型星形细胞分化弥漫性中线胶质瘤(DMG)MRI特征。方法 回顾性分析91例经病理确诊脊髓星形细胞分化DMG患者,根据H3K27M状态分为突变组(n=44)和野生组(n=47);观察组间临床和MRI表现差异,采用logistic回归分析筛选H3K27M突变的影响因素。结果 突变组瘤周水肿和脊髓空洞发生率均小于野生组(P均<0.05),其余组间差异均无统计学意义(P均>0.05)。将所有临床及MRI参数纳入logistic回归分析,结果显示其均非H3K27M突变的影响因素(P均>0.05)。结论 脊髓H3K27M突变型星形细胞分化DMG瘤周水肿和脊髓空洞发生率均低于野生型,但尚不足以作为预测DMG发生H3K27M突变的影响因素。
英文摘要:
      Objective To observe MRI features of H3K27M mutant type and wild type astrocyte differentiated diffuse midline glioma (DMG) in spinal cord. Methods Totally 91 patients with astrocyte differentiation diffuse midline glioma (DMG) in spinal cord confirmed by pathology were retrospectively enrolled and divided into mutant group (n=44) and wild group (n=47) according to H3K27M status. Clinical and MRI manifestations were compared between groups, and logistic regression analysis was used to screen the impact factors of H3K27M mutation. Results The incidence of peritumoral edema and spinal cord cavity in mutant group were lower than those in wild group (both P<0.05), while no significant difference of other parameters was found between groups (all P>0.05). All clinical and MRI parameters were included in logistic regression analysis, and the result showed that they were not influencing factors of H3K27M mutation (all P>0.05). Conclusion The incidence of peritumoral edema and spinal cord cavity in spinal cord H3K27M mutant type astrocyte differentiated DMG were lower than those of wild type, yet not sufficient to be regarded as impact factors for predicting H3K27M mutation of DMG.
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