| 李俊杰,梁倩,景辉.体素内不相干运动MRI预测脑胶质瘤异柠檬酸脱氢酶及1p/19q分子分型[J].中国医学影像技术,2024,40(6):805~809 |
| 体素内不相干运动MRI预测脑胶质瘤异柠檬酸脱氢酶及1p/19q分子分型 |
| Intravoxel incoherent motion MRI for predicting isocitrate dehydrogenase and 1p/19q molecular type of glioma |
| 投稿时间：2023-11-29 修订日期：2024-01-05 |
| DOI：10.13929/j.issn.1003-3289.2024.06.002 |
| 中文关键词: 胶质瘤 异柠檬酸脱氢酶 染色体 体素内不相干运动 |
| 英文关键词:glioma isocitrate dehydrogenase chromosomes intravoxel incoherent motion |
| 基金项目:国家自然科学基金(81971593)、太原市"六个一批"卫生健康人才能力提升科研项目(Y2023017)。 |
|
| 摘要点击次数: 338 |
| 全文下载次数: 304 |
| 中文摘要: |
| 目的 观察体素内不相干运动(IVIM)MRI预测脑胶质瘤异柠檬酸脱氢酶(IDH)及其1p/19q分子分型的价值。方法 回顾性纳入32例脑胶质瘤患者,根据IDH检测结果分为IDH突变组(n=18)及野生组(n=14),并根据染色体1p/19q检测结果将突变组分为1p/19q共缺失亚组(n=5)与非共缺失亚组(n=13)。比较组间、亚组间一般资料和IVIM参数,包括表观弥散系数(ADC)、慢弥散系数(D)、快弥散系数(D*)、灌注分数(f)、相对ADC(rADC)、相对D(rD)、相对D*(rD*)及相对f(rf)值,分析其预测脑胶质瘤分子分型的效能。结果 突变组患者年龄小于野生组(t=－4.274,P=0.001)。突变组ADC、rADC及D值高于野生组,D*及rf值低于野生组(P均＜0.05)。以ADC、rADC、D、D*及rf值预测脑胶质瘤IDH分型的曲线下面积(AUC)分别为0.80、0.76、0.74、0.78及0.72。共缺失亚组D*值大于非共缺失亚组(P＜0.05);以D*值预测IDH突变型脑胶质瘤1p/19q分型的AUC为0.88。结论 脑胶质瘤ADC、rADC、D、D*及rf值均有助于预测IDH突变,D*值还有助于预测染色体1p/19q共缺失。 |
| 英文摘要: |
| Objective To observe the value of intravoxel incoherent motion (IVIM) MRI for predicting isocitrate dehydrogenase (IDH) and 1p/19q molecular type of glioma. Methods Data of 32 patients with gliomas were retrospectively analyzed. The patients were divided into IDH mutation group (n=18) and wild group (n=14) based on IDH detection results, and those in mutation group were further divided into 1p/19q co deletion subgroup (n=5) and non co deletion subgroup (n=13) based on chromosome 1p/19q detection results. General information and IVIM parameters, including apparent diffusion coefficient (ADC), slow diffusion coefficient (D), fast diffusion coefficient (D*), perfusion fraction (f), relative ADC (rADC), relative D (rD), relative D* (rD*) and relative f (rf) values were compared between groups and subgroups, and the effectiveness of the above parameters for predicting molecular type of gliomas were analyzed. Results Patients' age in mutation group was younger than that in wild group (t=－4.274, P=0.001). ADC, rADC and D values of mutant group were all higher, while D* and rf values were both lower than those of wild group (all P＜0.05), and the area under the curve (AUC) of ADC, rADC, D, D* and rf values for predicting IDH type of glioma was 0.80, 0.76, 0.74, 0.78 and 0.72, respectively. D* value in co deletion subgroup was greater than that in non co deletion subgroup (P＜0.05), with AUC for predicting 1p/19q type of IDH mutant glioma of 0.88. Conclusion ADC, rADC, D, D* and rf values of glioma were all helpful for predicting IDH mutations, and D* value was also helpful for predicting chromosome 1p/19q co deletion. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
