薛明团,杜伟,曹家骏,蒋玉涵,宋段,张俊毅,苗延巍.δ-catenin表达水平对乳腺癌患者静息态脑功能的影响[J].中国医学影像技术,2024,40(5):724~729
δ-catenin表达水平对乳腺癌患者静息态脑功能的影响
Impact of δ-catenin expression level on resting-state brain function in breast cancer patients
投稿时间:2023-11-09  修订日期:2023-12-13
DOI:10.13929/j.issn.1003-3289.2024.05.019
中文关键词:  乳腺癌  磁共振成像
英文关键词:breast carcinoma  magnetic resonance imaging
基金项目:内蒙古自治区高等学校科学研究项目(NJZY22190)、内蒙古自治区卫生健康委医疗卫生科技计划项目(202202336)。
作者单位E-mail
薛明团 大连医科大学附属第一医院放射科, 辽宁 大连 116011
赤峰学院附属医院CT、MR科, 
 
杜伟 大连医科大学附属第一医院放射科, 辽宁 大连 116011  
曹家骏 大连医科大学附属第一医院放射科, 辽宁 大连 116011  
蒋玉涵 大连医科大学附属第一医院放射科, 辽宁 大连 116011  
宋段 赤峰学院附属医院CT、MR科,  
张俊毅 病理科, 内蒙古 赤峰 024000  
苗延巍 大连医科大学附属第一医院放射科, 辽宁 大连 116011 ywmiao716@163.com 
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中文摘要:
      目的 观察δ-catenin表达水平对乳腺癌患者静息态脑功能的影响。方法 前瞻性纳入104例女性乳腺癌患者,根据δ-catenin表达水平将其分为高表达组(DH组,n=51)及低表达组(DL组,n=53);另以36名女性健康志愿者为对照组。行神经心理学测试;采集静息态功能MRI(rs-fMRI),记录组间脑功能参数存在差异脑区;以Spearman相关分析上述脑区脑功能参数 与受试者一般资料及神经心理学测试评分结果的相关性。结果 3组fALFF、ReHo及FCS值差异均有统计学意义 。DH组及DL组左侧颞下回fALFF值均高于对照组(FWE校正,P均<0.05);DH组右侧颞下回及DL组右侧颞中回、右侧颞下回、右侧梭状回ReHo值均低于对照组(FWE校正,P均<0.05);DH组左侧豆状核、左侧壳核、左侧梭状回、左侧距状裂周围皮层及左侧颞下回FCS值均高于DL组(FWE校正,P均<0.05),DH组左侧豆状核、左侧壳核、左侧梭状回、左侧距状裂周围皮层FCS值均高于对照组(FWE校正,P均<0.05),DL组左侧舌回、左侧豆状核及左侧壳核FCS值均高于对照组(FWE校正,P均<0.05)。DH组与DL组存在差异脑区FCS值与CogPCA结果呈低度正相关(r=0.313,P<0.05)。DH组与对照组存在差异脑区的fALFF值与连线测试A(TMT A)及连线测试B(TMT B)结果均呈低度正相关(r=0.301、0.310,P均<0.05),ReHo值与TMT B结果呈低度负相关(r=-0.307,P<0.05),FCS值与TMT A、TMT B呈弱/低度正相关(r=0.282、0.309,P均<0.05)、与数字符号替代测试(DSST)呈低度负相关(r=-0.363,P<0.05)。DL组与对照组存在差异脑区的fALFF值与简易精神状态检查(MMSE)、蒙特利尔认知评估(MoCA)、中文听觉词汇学习测验(AVLT)短时记忆及DSST呈弱/低度负相关(r=-0.399、-0.362、-0.344、-0.288,P均<0.05)。结论 δ-catenin表达水平对乳腺癌患者脑功能有一定影响,可致双侧大脑半球脑网络非对称性改变,并通过影响左侧颞下回、左侧豆状核、左侧壳核及左侧梭状回致记忆力下降。
英文摘要:
      Objective To explore the impact of δ-catenin expression level on resting-state brain function in breast cancer patients. Methods Totally 104 female breast cancer patients were prospectively enrolled and divided into δ-catenin high expression group (DH group, n=51) and δ-catenin low expression group (DL group, n=53) according to δ-catenin expression level, while 36 female healthy volunteers were selected as controls (control group). Neuropsychological tests were performed, and resting-state functional MRI (rs-fMRI) were acquired, then parameters of brain function, including amplitude of low frequency fluctuation (ALFF), fractional ALFF (fALFF), regional homogeneity (ReHo) and functional connectivity strength (FCS) of brain regions with differences among groups were obtained. Spearman correlation analysis was used to evaluate the correlations of function parameters of brain regions with general data and neuropsychological test scores. Results Significant differences of fALFF, ReHo and FCS values were found among 3 groups (familywise error rate correction, all P<0.05). fALFF value of left inferior temporal gyrus in DH and DL groups were both higher than that in control group (FWE correction, both P<0.05), ReHo value of right inferior temporal gyrus in DH group, as well as of right middle temporal gyrus, right inferior temporal gyrus and right fusiform gyrus in DL group were all lower than that in control group (FWE correction, all P<0.05), FSC value of left lenticular nucleus, left putamen, left fusiform gyrus, left calcarine fissure surrounding cortex and left inferior temporal gyrus in DH group were all higher than that in DL group (FWE correction, all P<0.05), FSC value of left lenticular nucleus, left putamen, left fusiform gyrus and left calcarine fissure surrounding cortex in DH group were all higher than that in control group (FWE correction, all P<0.05), while FSC value of left lingual gyrus, left lenticular nucleus and left putamen were both higher than that in control group (FWE correction, both P<0.05). In brain regions with different fMRI indexes between DH group and DL group, FSC values were lowly positively correlated with CogPCA results (r=0.313, P<0.05). In brain regions with different fMRI indexes between DH group and control group, fALFF value were lowly positively correlated with trail making test A (TMT A) and trail making test B (TMT B) (r=0.301, 0.310, both P<0.05), ReHo values were lowly negatively correlated with TMT B (r=-0.307, P<0.05), FCS values were weakly/lowly positively correlated with TMT A and TMT B (r=0.282, 0.309, both P<0.05) and lowly negatively correlated with results of digital symbol substitution test (DSST) (r=-0.363, P<0.05). In brain regions with different fMRI indexes between DL group and control group, fALFF values were weakly/lowly negatively correlated with results of mini mental state examination (MMSE), Montreal cognitive assessment (MoCA), auditory verbal learning test (AVLT) short-term memory and DSST (r=-0.399, -0.362, -0.344, -0.288, all P<0.05). Conclusion The expression level of δ-catenin had certain impact on brain function of breast cancer patients, resulted in asymmetry changes of brain network in bilateral hemispheres, as well as memory loss through affecting left inferior temporal gyrus, left lenticular nucleus, left putamen and left fusiform gyrus.
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