雷婷,闫伟,唐思维,周慧玲,李海青,蒋玉星,贺曦,何淼,宋佳芮,周立静,李亚君,陈莉.静息态功能MRI观察脑小血管病患者额顶网络功能连接与认知功能的关系[J].中国医学影像技术,2024,40(5):718~723
静息态功能MRI观察脑小血管病患者额顶网络功能连接与认知功能的关系
Resting-state functional MRI observation on relationship between functional connectivity of frontoparietal network and cognitive function in patients with cerebral small vessel disease
投稿时间:2023-11-28  修订日期:2024-01-04
DOI:10.13929/j.issn.1003-3289.2024.05.018
中文关键词:  脑血管疾病  认知  磁共振成像  功能连接
英文关键词:cerebrovascular disorders  cognition  magnetic resonance imaging  functional connectivity
基金项目:南充市市校科技战略合作专项(20SXZRKX0011)、国家临床重点专科建设项目 。
作者单位E-mail
雷婷 川北医学院附属医院放射科, 四川 南充 637000  
闫伟 川北医学院附属医院放射科, 四川 南充 637000  
唐思维 川北医学院附属医院放射科, 四川 南充 637000  
周慧玲 川北医学院附属医院放射科, 四川 南充 637000  
李海青 川北医学院附属医院放射科, 四川 南充 637000  
蒋玉星 川北医学院附属医院放射科, 四川 南充 637000  
贺曦 川北医学院附属医院放射科, 四川 南充 637000  
何淼 中国医学科学院 北京协和医学院 北京协和医院放射科, 北京 100730  
宋佳芮 重庆两江新区人民医院核医学科, 重庆 388617  
周立静 资阳市人民医院放射科, 四川 资阳 641300  
李亚君 南充市第三人民医院放射科, 四川 南充 637000  
陈莉 川北医学院附属医院放射科, 四川 南充 637000 chenliidea@sina.com 
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中文摘要:
      目的 采用静息态功能MRI(rs-fMRI)观察脑小血管病(CSVD)患者额顶网络(FPN)功能连接(FC)与认知功能的关系。方法 回顾性分析50例CSVD认知障碍患者(CI组)、65例CSVD认知正常患者(NC组)和60名健康对照者(HC组)头颅rs-fMRI及神经心理学测试结果;比较3组间及两两FPN FC存在差异的脑区;采用偏相关分析评估CI组与NC组间存在差异脑区FC值与认知评分的相关性。结果 3组双侧扣带回、左侧额中回、右侧缘上回、右侧顶下小叶及右内侧额上回FC存在差异(FWE校正,P均<0.05)。相比NC组,CI组左侧扣带回FC减弱而右侧额下回及右内侧额上回FC增强(FWE校正,P均<0.05)。CSVD患者左侧扣带回FC减弱与画钟测验评分呈负相关(r=-0.159,P=0.049)。结论 CSVD患者无论伴或不伴CI均存在广泛FPN FC改变;左侧扣带回与CSVD患者认知功能相关。
英文摘要:
      Objective To observe the relationship between functional connectivity (FC) of frontoparietal network (FPN) and cognitive function in patients with cerebral small vessel disease (CSVD) using resting-state functional MRI (rs-fMRI). Methods rs-fMRI of 50 CSVD patients with cognitive impairment (CI group), 65 CSVD patients with normal cognition (NC group) and 60 healthy controls (HC group), as well as outcomes of neuropsychological tests were retrospectively analyzed. Brain regions with different FC of FPN were compared among 3 groups and between each 2 groups. Partial correlation analysis was used to evaluate the correlations of FC of brain regions value being statistically different between CI and NC groups and cognitive scores. Results Significant differences of FC in bilateral cingulate gyrus, left middle frontal gyrus, right supramarginal gyrus, right inferior parietal lobule and right medial superior frontal gyrus were found among groups (FWE correction, all P<0.05). Compared with NC group, FC of left cingulate gyrus decreased, of right inferior frontal gyrus and right medial superior frontal gyrus increased in CI group (FWE correction, all P<0.05). The decreased FC value of left cingulate gyrus was negatively correlated with clock drawing test score in CSVD patients (r=-0.159, P=0.049). Conclusion CSVD patients with or without CI had extensive abnormal FC of FPN, and the left cingulate gyrus was associated with patient's cognitive function.
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