詹鹏超,刘星,李亚华,吴锟鹏,李臻,吕培杰,梁盼,高剑波.不同双能CT虚拟单能谱图像衍生影像组学特征的可重复性:实验研究[J].中国医学影像技术,2024,40(5):712~717
不同双能CT虚拟单能谱图像衍生影像组学特征的可重复性:实验研究
Reproducibility of virtual monoenergetic CT image-derived radiomics features: Experimental study
投稿时间:2023-09-10  修订日期:2024-01-17
DOI:10.13929/j.issn.1003-3289.2024.05.017
中文关键词:  肝肿瘤,实验性    体层摄影术,X线计算机  影像组学  可重复性,结果
英文关键词:liver neoplasms, experimental  rabbits  tomography, X-ray computed  radiomics  reproducibility of results
基金项目:
作者单位E-mail
詹鹏超 郑州大学第一附属医院放射科, 河南 郑州 450052  
刘星 郑州大学第一附属医院放射科, 河南 郑州 450052  
李亚华 郑州大学第一附属医院放射介入科, 河南 郑州 450052
河南省介入治疗与临床研究中心, 河南 郑州 450052 
 
吴锟鹏 郑州大学第一附属医院放射科, 河南 郑州 450052
河南省介入治疗与临床研究中心, 河南 郑州 450052 
 
李臻 郑州大学第一附属医院放射介入科, 河南 郑州 450052  
吕培杰 郑州大学第一附属医院放射科, 河南 郑州 450052  
梁盼 郑州大学第一附属医院放射科, 河南 郑州 450052  
高剑波 郑州大学第一附属医院放射科, 河南 郑州 450052 cjr.gaojianbo@vip.163.com 
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中文摘要:
      目的 比较3种双能CT(DECT)系统在不同条件下所获VX2兔肝肿瘤模型虚拟单能谱图像(VMI)增强CT影像组学特征(RF)的可重复性及其与诊断效能的关系。方法 将15只VX2兔肝肿瘤模型随机均分为3组,分别接受采用双源DECT(dsDECT)、快速kV切换DECT(rsDECT)或双层探测器DECT(dlDECT)于不同体积CT剂量指数(CTDIvol)(6、9及12 mGy)下腹部增强CT扫描,于40~140 keV内每间隔10 keV重建单能图像并提取RF;以组内相关系数(ICC)计算RF可重复性,以ICC≥0.80为可重复RF,比较不同CT仪配对之间及不同CTDIvol下可重复RF占比(R),以及相同CTDIvol下不同CT仪配对可重复RF数量(N)最大值相应重建能量水平;绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),比较最佳可重复条件下可重复RF与其他RF的诊断效能,计算RF的ICC与相应AUC的Spearman相关系数。结果 RrsDECT-dsDECT[6.45%, 95% CI(2.36%, 8.87%)] 高于 RdlDECT-dsDECT [0.72%, 95% CI(0.15%, 1.79%)]及RrsDECT-dlDECT[1.43%, 95% CI(0.60%, 4.06%)] (校正P均<0.05);R9mGy[3.70%, 95% CI(1.31%, 5.73%)] 及R12mGy [2.63%, 95% CI(0.60%, 6.69%)] 高于R6mGy [1.31%, 95% CI(0.12%, 1.55%)](校正P均<0.05)。6、9及12 mGy下,RF最佳可重复重建能量水平集中于50~70 keV,可重复RF的AUC均高于其他RF(校正P均<0.05),且RF可重复性与诊断效能相关(rs=0.102~0.516,P<0.05)。结论 兔肝肿瘤模型VMI CT增强图像RF可重复性与DECT设备、CTDIvol水平及重建能量水平相关,可重复RF可能诊断效能更佳。
英文摘要:
      Objective To observe the reproducibility of radiomics feature (RF) extracted from virtual monoenergetic image (VMI) of rabbit VX2 hepatoma models obtained with 3 different dual-energy CT (DECT) systems, and to explore relationship of reproducibility and diagnostic performance of RF. Methods Fifteen rabbits with VX2 hepatoma were randomly divided into 3 groups (each n=5). Contrast-enhanced abdominal CT scanning under volume CT dose index (CTDIvol) levels of 6, 9 and 12 mGy were performed with dual-source DECT (dsDECT), rapid kV switching DECT (rsDECT) and dual-layer detector DECT (dlDECT), respectively. VMI were reconstructed at 10 keV increments from 40 to 140 keV. RF were extracted from VMI, the reproducibility was assessed using intra-class correlation coefficient (ICC), and those with ICC≥0.8 were considered as reproducible RF. The percentage of reproducible features (denoted by R) were compared among different scanner pairings and different CTDIvol levels. Within each CTDIvol group, the reconstruction energy levels yielding the maximum number (denoted by N) of common RF across different scanner pairings were identified. The receiver operating characteristic (ROC) curve was drawn, the area under the curve (AUC) was calculated, and the diagnostic efficacies of reproducible RF and other RF were compared under optimal reproducible conditions. Spearman correlation coefficient between ICC and the corresponding AUC of RF were calculated. Results RrsDECT-dsDECT (6.45%, 95%CI[2.36 %, 8.87 %]) was higher than RdlDECT-dsDECT (0.72%, 95%CI[0.15 %, 1.79 %]) and RrsDECT-dlDECT (1.43%, 95%CI[0.60 %, 4.06 %]) (all adjusted P<0.05), R9mGy (3.70%, 95%CI[1.31 %, 5.37 %]) and R12mGy (2.63%, 95%CI[0.60 %, 6.69 %]) were higher than R6mGy (1.31%, 95%CI[0.12 %, 1.55 %]) (all adjusted P<0.05). The optimal reproducible reconstruction energy levels of RF under CTDIvol of 6, 9 and 12 mGy concentrated at 50—70 keV. AUC of reproducible RFs were higher than of other RF (all adjusted P<0.05) and had certain correlation with the reproducibility (rs=0.102-0.516, P<0.05). Conclusion The reproducibility of RF extracted from contrast-enhanced VMI CT images of rabbit VX2 hepatoma models associated with DECT scanner, CTDIvol level and reconstruction energy level. RF with higher reproducibility might have better diagnostic performance.
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