刘建宪,王振松,李正义,王鑫,于丹,杨燕兴,程传力,邹超,陈硕,甘洁.5.0T与1.5T MR波谱定量肝脏质子密度脂肪分数的一致性[J].中国医学影像技术,2024,40(5):677~681
5.0T与1.5T MR波谱定量肝脏质子密度脂肪分数的一致性
Consistency of 5.0T and 1.5T MR spectroscopy for quantitating proton density fat fraction of liver
投稿时间:2023-12-14  修订日期:2024-03-23
DOI:10.13929/j.issn.1003-3289.2024.05.009
中文关键词:    磁共振波谱  前瞻性研究  质子密度脂肪分数
英文关键词:liver  magnetic resonance spectroscopy  prospective studies  proton density fat fraction
基金项目:山东省医药卫生科技发展计划项目(202209010957)。
作者单位E-mail
刘建宪 山东大学附属山东省立第三医院影像中心, 山东 济南 250032  
王振松 山东大学附属山东省立第三医院影像中心, 山东 济南 250032  
李正义 山东大学附属山东省立第三医院影像中心, 山东 济南 250032  
王鑫 山东大学附属山东省立第三医院影像中心, 山东 济南 250032  
于丹 北京联影智能影像技术研究院, 北京 100094  
杨燕兴 上海联影医疗科技股份有限公司, 上海 201807  
程传力 中国科学院深圳先进技术研究院劳特伯生物医学成像研究中心, 广东 深圳 518055  
邹超 中国科学院深圳先进技术研究院劳特伯生物医学成像研究中心, 广东 深圳 518055  
陈硕 北京联影智能影像技术研究院, 北京 100094  
甘洁 山东大学附属山东省立第三医院影像中心, 山东 济南 250032 ganjie000@sina.com 
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中文摘要:
      目的 观察5.0T与1.5T MR波谱(MRS)定量肝脏质子密度脂肪分数(PDFF)的一致性。方法 分别以5.0T及1.5TMR仪对脂质含量各为0、5%、10%、15%、20%、25%及30%的脂质乳液模型采集1H-MRS,以jMRUI软件分析获得PDFF。前瞻性对11例脂肪肝患者及12名健康成人肝脏感兴趣容积(VOI)采集1H-MRS,分别以jMRUI软件及相应工作站进行分析并获得PDFF。观察各方法所测脂质乳液模型及肝脏PDFF的一致性。结果 针对脂质含量0、5%、10%、15%、20%、25%及30%的脂质乳液模型,以jMRUI软件基于5.0T与1.5T 1H-MRS所测PDFF均一致性良好并呈正相关。针对全部人体肝脏VOI,以jMRUI软件及工作站针对5.0T与1.5T 1H-MRS所测的PDFF亦均一致性良好且均呈正相关。结论 5.0T与1.5T 1H-MRS用于定量肝脏PDFF一致性良好且呈正相关;临床以工作站测量肝脏PDFF有利于简化工作流程。
英文摘要:
      Objective To observe the consistency of 5.0T and 1.5T MR spectroscopy (MRS) for quantitating proton density fat fraction (PDFF) of liver. Methods Lipid emulsion models with lipid content of 0, 5%, 10%, 15%, 20%, 25% and 30% were prepared. 1H-MRS were collected using 5.0T and 1.5T MR scanners, respectively, and PDFF were obtained with jMRUI software. Totally 23 people, including 11 cases of fatty liver and 12 healthy adults were prospectively collected, and volume of interest (VOI) in the liver were selected to acquire 1H-MRS, and PDFF were obtained with jMRUI software and corresponding workstation, respectively. The consistencies of PDFF measured with different methods were analyzed. Results PDFF of lipid emulsion models with lipid content of 0, 5%, 10%, 15%, 20%, 25% and 30% measured with jMRUI software and workstations based on 5.0T and 1.5T 1H-MRS all had good consistencies and being positively correlated, so were PDFF of liver tissue measured with jMRUI software and workstations based on 5.0T and 1.5T 1H-MRS. Conclusion 5.0T and 1.5T 1H-MRS had good consistency for quantitating liver PDFF. Measuring liver PDFF with workstation in clinical practice was helpful to simplifying workflow.
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