| 李冬雪,范晓媛,韩华璐,陈硕,孙伟,有慧,李明利,冯逢.5.0T全脑准连续动脉自旋标记MRI参数优化[J].中国医学影像技术,2024,40(5):643~647 |
| 5.0T全脑准连续动脉自旋标记MRI参数优化 |
| Optimization for parameters of 5.0T pseudo continuous arterial spin labeling MRI of whole brain |
| 投稿时间：2024-02-05 修订日期：2024-03-29 |
| DOI：10.13929/j.issn.1003-3289.2024.05.002 |
| 中文关键词: 脑 动脉自旋标记 磁共振成像 图像质量 前瞻性研究 |
| 英文关键词:brain arterial spin labeling magnetic resonance imaging image quality prospective studies |
| 基金项目:国家自然科学基金面上项目(82071899、82371946)、中国医学科学院医学与健康科技创新工程(2021-I2M-1-025)、北京市自然科学基金(7222131)。 |
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| 中文摘要: |
| 目的 探讨5.0T全脑准连续动脉自旋标记(pCASL) MRI参数优化。方法 前瞻性招募9名健康成人,利用5.0T MR仪行单延迟pCASL扫描,设置3组标记梯度:A组,平均梯度(Gavg)=1 mT/m,最大梯度(Gmax)与Gavg比值(Gratio)=10;B组,Gavg=0.6 mT/m,Gratio=10;C组,Gavg=0.3 mT/m,Gratio=9。比较3组标记效率及脑血流量(CBF);筛选最佳标记梯度组。结果 标记血流平均速度为40 cm/s、B1+降低和B0偏移频率较大时,C组梯度场容纳度优于A、B组。C组梯度场下,标记动脉B1水平为54.19%~75.36%、平均64.71%;该组标记效率均≥85%平均B1水平(64.71%)下标记效率均≥90%。C组梯度场下pCASL采集的全脑灰质和几乎所有脑区的CBF明显高于A、B组(P均<0.05)。 结论 低Gavg及低Gmax为5.0T全脑pCASL MRI最佳参数。 |
| 英文摘要: |
| Objective To explore the optimization for parameters of 5.0T pseudo continuous arterial spin labeling (pCASL) MRI of whole brain. Methods Nine healthy adults were prospectively enrolled, and single-delay pCASL scanning was performed based on a 5.0T MR scanner with 3 sets of labeling gradients: Group A, average gradient (Gavg)=1 mT/m and the ratio of maximum gradient (Gmax) to Gavg (Gratio)=10, group B, Gavg=0.6 mT/m and Gratio=10, group C, Gavg=0.3 mT/m and Gratio=9. The labeling efficiency and cerebral blood flow (CBF) of 3 groups were compared to screen the best labeling gradient group. Results When the marked average blood flow velocity was 40 cm/s, the gradient field tolerance of group C was better than that of group A and B at the situation of reduced B1+ and larger B0 offset frequency range. Under the gradient field of group C, the level of labeled artery B1 ranged from 54.19% to 75.36%, with an average of 64.71%. The labeling efficiencies of group C were all ≥85%, and all ≥90% at the average B1 level (64.71%). In the whole gray matter and almost all brain regions, CBF on pCASL under gradient field of group C was significantly higher than that of group A and B (all P<0.05). Conclusion Low Gavg and low Gmax were the optimal parameters for 5.0T whole brain pCASL MRI. |
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