| 李旭,马培旗,张小艳,王仲秋,李小伟,许星成,张磊.肝、脾及腰椎R2*值评估慢性肾衰竭患者体内铁含量[J].中国医学影像技术,2024,40(3):412~415 |
| 肝、脾及腰椎R2*值评估慢性肾衰竭患者体内铁含量 |
| Liver, spleen and lumbar R2* values for evaluating iron content in patients with chronic kidney failure |
| 投稿时间：2023-09-05 修订日期：2024-01-08 |
| DOI：10.13929/j.issn.1003-3289.2024.03.019 |
| 中文关键词: 肾衰竭,慢性 铁 磁共振成像 |
| 英文关键词:kidney failure, chronic iron magnetic resonance imaging |
| 基金项目:2020年阜阳市自筹经费科技计划项目(FK202081048)。 |
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| 中文摘要: |
| 目的 观察肝、脾及腰椎R2*值用于评估慢性肾衰竭(CKD)患者体内铁含量的价值。方法 回顾性纳入52例CKD患者,根据转铁蛋白饱和度≤20%与否分为绝对缺铁组(n=22)和非绝对缺铁组(n=30)。基于改良Dixon定量(mDIXON-quant)MRI观察组间肝、脾及腰椎R2*值差异,并分析上述R2*值与铁代谢指标的相关性;行logistic回归分析,观察绝对缺铁的影响因素,并分析其诊断效能。结果 绝对缺铁组与非绝对缺铁组脾和腰椎R2*值差异均有统计学意义(P均＜0.05)。CKD患者脾、腰椎R2*值与铁蛋白、转铁蛋白饱和度均呈正相关(P均＜0.05),与不饱和铁结合力、总铁结合力及转铁蛋白呈负相关(P均＜0.05)。腰椎R2*值减低是CKD患者绝对缺铁的影响因素(P＜0.05)。以腰椎R2*值=134.26 Hz为最佳截断值,其诊断CKD患者绝对缺铁的敏感度为86.70%,特异度为68.20%,曲线下面积为0.727。结论 腰椎R2*值有助于评估CKD患者体内铁含量。 |
| 英文摘要: |
| Objective To observe the value of liver, spleen and lumbar R2* values for evaluating iron content in patients with chronic kidney failure (CKD). Methods Totally 52 CKD patients were retrospectively enrolled and divided into absolute iron deficiency group (n=22) or non absolute iron deficiency group (n=30) based on transferrin saturation≤20% or not. Based on modified Dixon quantification (mDIXON-quant) MRI, liver, spleen and lumbar R2* values were compared between groups, and the correlations between the above R2* values and iron metabolism parameters were analyzed. Logistic regression analysis was performed, the influencing factors of absolute iron deficiency and the diagnostic efficiency were analyzed. Results There were significant differences of spleen and lumbar R2* values between absolute iron deficiency group and non absolute iron deficiency group (both P＜0.05). The spleen and lumbar R2* values in CKD patients were positively correlated with ferritin and transferrin saturation (all P＜0.05), negatively correlated with unsaturated iron binding force, total iron binding force and transferrin (all P＜0.05). The lumbar R2* value decreased was an influencing factor of absolute iron deficiency in CKD patients (P＜0.05). Taken lumbar R2* value=134.26 Hz as the best cutoff value, the sensitivity, specificity and the area under the curve for diagnosing absolute iron deficiency in CKD patients was 86.70%, 68.20% and 0.727, respectively. Conclusion Lumbar R2* value was helpful for evaluating iron content in CKD patients. |
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