| 富璐,潘晓芳,马舒贝,刘毅,张博,吴欣倩,孙娜.经颅超声中缝核显像诊断卒中后抑郁[J].中国医学影像技术,2022,38(6):821~824 |
| 经颅超声中缝核显像诊断卒中后抑郁 |
| Raphe nuclei imaging of transcranial sonography for diagnosing poststroke depression |
| 投稿时间：2021-10-07 修订日期：2022-03-18 |
| DOI：10.13929/j.issn.1003-3289.2022.06.006 |
| 中文关键词: 脑卒中 抑郁 中缝核 超声检查 前瞻性研究 |
| 英文关键词:stroke depression raphe nuclei ultrasonography prospective studies |
| 基金项目:大连市科技创新计划科技惠民项目（2021JJ13SN64）。 |
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| 中文摘要: |
| 目的 观察经颅超声（TCS）中缝核显像诊断卒中后抑郁（PSD）的价值。方法 前瞻性纳入195例疑诊PSD的缺血性脑卒中患者，因声窗条件较差排除21例，将纳入的174例依据临床系统评估及量表评分分为PSD组（n=141）和非PSD组（n=33），比较组间基本资料及临床量表评分差异；根据组间中缝核回声改变情况，分析TCS诊断PSD的效能，评价PSD组患者汉密尔顿抑郁量表（HAMD）评分与中缝核回声分级的相关性。结果 组间患者性别、HAMD和汉密尔顿焦虑量表（HAMA）评分差异均有统计学意义（P均<0.05）。PSD组中缝核回声异常比例明显高于非PSD组（75.89%vs.9.09%，P<0.01）。根据中缝核回声异常诊断PSD的敏感度、特异度及准确率分别为75.89%、90.91%及78.74%。PSD组患者HAMD评分等级与中缝核回声分级呈负相关（R=－0.58，P<0.01）。结论 TCS可定性和半定量评估并辅助诊断PSD。 |
| 英文摘要: |
| Objective To observe the value of transcranial ultrasound (TCS) raphe nuclei imaging for diagnosing poststroke depression (PSD). Methods Totally 195 cerebral ischemic stroke patients with suspected PSD were prospectively enrolled. Twenty-one patients were excluded due to poor sound window conditions. Then 174 patients were divided into PSD group (n=141) and non-PSD group (n=33) according to clinical systematic assessment and scale scores. The differences of basic information and clinical scale scores were compared between groups. The efficiency of TCS for diagnosing PSD was analyzed according to the changes of raphe nuclei echogenicity between groups. The correlations of Hamilton depression rating scale (HAMD) scores and raphe nuclei echogenicity grades were evaluated in PSD group. Results There were significant differences of patients' gender, HAMD and Hamilton anxiety scale (HAMA) scores between groups (all P<0.05). The proportion of abnormal raphe nuclei echogenicity in PSD group was significantly higher than that in non-PSD group (75.89% vs. 9.09%, P<0.01). The sensitivity, specificity and accuracy of raphe nuclei for diagnosing PSD was 75.89%, 90.91% and 78.74%, respectively. There was a negative correlation between HAMD score and raphe nuclei echogenicity grade in PSD group (R=-0.58, P<0.01). Conclusion TCS could qualitatively and semi-quantitatively assess and assist diagnosis of PSD. |
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