| 吴伟,陈婷,吴小佳,罗银灯.快速波谱成像用于急性缺血性脑卒中[J].中国医学影像技术,2022,38(2):172~176 |
| 快速波谱成像用于急性缺血性脑卒中 |
| Turbo spectroscopic imaging in acute ischemic stroke |
| 投稿时间：2021-05-17 修订日期：2021-08-19 |
| DOI：10.13929/j.issn.1003-3289.2022.02.004 |
| 中文关键词: 脑卒中 磁共振成像 磁共振波谱 |
| 英文关键词:stroke magnetic resonance imaging magnetic resonance spectroscopy |
| 基金项目: |
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| 中文摘要: |
| 目的 评价快速波谱成像（TSI）技术用于急性缺血性脑卒中（AIS）的价值。方法 对40例AIS患者行TSI及常规多体素化学位移波谱成像（CSI），采用对应频谱拟合脚本获得N-乙酰天冬氨酸（NAA）、肌酸复合物（Cr）、胆碱复合物（Cho）、乳酸（Lac）峰下面积及NAA、Cho、Lac与Cr的比值；将TSI和CSI拟合后获得的NAA和Lac分布伪彩图分割后与弥散加权成像（DWI）相融合，分析其匹配程度。结果 相比周边正常脑组织，梗死边缘区NAA稍降低，梗死核心区NAA降低程度大于梗死边缘区，Lac则呈相反趋势；梗死周边正常脑组织存在少量Lac分布。TSI与CSI数据经拟合的代谢物分布差异无明显统计学意义（P均>0.05）。TSI与CSI分别显示33例及32例NAA伪彩图暗区分布小于DWI高信号区，Lac伪彩图高亮区明显大于DWI高信号区。结论 采用TSI可在较短时间内完成采集，并获得与常规CSI基本一致的代谢物分布数据。AIS患者代谢物分布伪彩图可能与DWI高信号区不匹配。 |
| 英文摘要: |
| Objective To observe the value of turbo spectroscopic imaging (TSI) in acute ischemic stroke (AIS). Methods Forty patients with AIS who underwent TSI and conventional multi-voxel chemical shift imaging (CSI) were enrolled. The corresponding spectrum fitting script was used to obtain the area under curve of N-acetyl aspartate (NAA), creatine complex (Cr), choline-containing compounds (Cho), lactate (Lac), as well as the ratio of NAA, Cho and Lac with Cr. The NAA and Lac distribution pseudo-color images obtained after TSI and CSI fitting were segmented and fused with diffusion weighted imaging (DWI), and the matching degrees were analyzed. Results Compared with peripheral normal brain, NAA decreased slightly in the marginal infarct area, while somehow obviously in the core area of infarct, whereas Lac showed opposite trend. A small amount of Lac distribution could be detected in peripheral normal brain. There was no significant difference of the distribution of metabolites between TSI and CSI data (all P>0.05). TSI and CSI showed that the dark area in NAA pseudo-color map was less than high signal area on DWI, and the bright area in Lac pseudo-color map was significantly greater than high signal area on DWI in 33 and 32 patients, respectively. Conclusion TSI could complete the collection in a short time and obtain metabolite distribution data basically consistent with conventional CSI. The metabolite distribution on pseudo-color map might be mismatched with high signal area on DWI in AIS patients. |
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