罗玲玲,汪世存,姚晓波,金晓毛,张然,夏俊勇,卞岍雨.分化型甲状腺癌术后患者131I治疗后全身显像中肝脏弥漫性摄取的临床意义[J].中国医学影像技术,2021,37(7):1020~1024
分化型甲状腺癌术后患者131I治疗后全身显像中肝脏弥漫性摄取的临床意义
Clinical significances of diffuse liver uptake in 131I post-therapy whole body imaging of patients with differentiated thyroid carcinoma after surgical resection
投稿时间:2020-04-07  修订日期:2021-03-01
DOI:10.13929/j.issn.1003-3289.2021.07.013
中文关键词:  甲状腺肿瘤  放射性核素显像  肝脏弥漫性摄取
英文关键词:thyroid neoplasms  radionuclide imaging  diffuse liver uptake
基金项目:
作者单位E-mail
罗玲玲 中国科学技术大学附属第一医院核医学科, 安徽 合肥 230002 526LLL@sina.com 
汪世存 中国科学技术大学附属第一医院核医学科, 安徽 合肥 230002  
姚晓波 中国科学技术大学附属第一医院核医学科, 安徽 合肥 230002  
金晓毛 中国科学技术大学附属第一医院核医学科, 安徽 合肥 230002  
张然 中国科学技术大学附属第一医院核医学科, 安徽 合肥 230002  
夏俊勇 中国科学技术大学附属第一医院核医学科, 安徽 合肥 230002  
卞岍雨 中国科学技术大学附属第一医院核医学科, 安徽 合肥 230002  
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中文摘要:
      目的 探讨分化型甲状腺癌(DTC)术后患者131I治疗后全身显像(Rx-WBS)中肝脏弥漫性摄取(DHU)的临床意义。方法 回顾性分析178例DTC,根据Rx-WBS所示DHU程度将其分为G0组(n=41)、G1组(n=69)、G2组(n=56)和G3组(n=12);将P<0.2的因素纳入有序Logistic回归分析,筛选DHU影响因素。结果 178例DTC中,137例(137/178,76.97%)可见DHU。单因素分析显示4组患者促甲状腺激素(TSH)、131I剂量及远处转移(M)差异均有统计学意义(P均<0.05),而年龄、甲状腺球蛋白(Tg)等11个因素差异均无统计学意义(P均>0.05)。多因素有序Logistic回归分析显示131I剂量(β=0.013,P=0.036)是DHU程度的独立影响因素;4组间TSH、M、治疗次数及Tg差异均无统计学意义(P均>0.05)。结论 131I剂量是DHU程度的独立影响因素,且具有显著正向影响。
英文摘要:
      Objective To explore the clinical significance of diffuse hepatic uptake (DHU) in 131I post-therapy whole body scan (Rx-WBS) of patients with differentiated thyroid carcinoma (DTC) after surgical resection. Methods Data of 178 DTC patients after surgical resection were retrospectively analyzed. According to the degrees of DHU in Rx-WBS, the patients were divided into group G0 (n=41), group G1 (n=69), group G2 (n=56) and group G3 (n=12), respectively. The factors with P<0.2 were put into orderly Logistic regression analysis to explore the impact factors of the degrees of DHU. Results Totally 137 patients (137/178, 76.97%) were found with DHU. Single factor analysis showed that there were significant differences of thyroid stimulating hormone (TSH), 131I dose and distant metastases (M) among 4 groups (all P<0.05), but not of age, thyroglobulin (Tg) nor other 11 factors (all P>0.05). Orderly Logistic regression analysis showed that 131I dose (β=0.013, P=0.036) was an independent impact factor of DHU degree, while no statistical difference of TSH, M, times of treatment nor Tg was detected (all P>0.05). Conclusion 131I dose was an independent impact factor of DHU degree, which had significant positive effect on the degree of DHU.
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