冯晓蕾,何鑫,周琦,姜珏.剪切波弹性成像技术定量评价亚临床性甲状腺功能减退症患者颈动脉弹性[J].中国医学影像技术,2021,37(7):989~992
剪切波弹性成像技术定量评价亚临床性甲状腺功能减退症患者颈动脉弹性
Shear wave elastography for quantitative evaluation on carotid elasticity in patients with subclinical hypothyroidism
投稿时间:2020-08-18  修订日期:2021-05-21
DOI:10.13929/j.issn.1003-3289.2021.07.006
中文关键词:  甲状腺功能减退症  颈动脉  弹性成像技术
英文关键词:hypothyroidism  carotid arteries  elasticity imaging techniques
基金项目:国家自然科学基金面上项目(81871366)。
作者单位E-mail
冯晓蕾 西安交通大学第二附属医院超声研究室, 陕西 西安 710004  
何鑫 西安交通大学第二附属医院超声研究室, 陕西 西安 710004  
周琦 西安交通大学第二附属医院超声研究室, 陕西 西安 710004 zhouqi1998@yahoo.com.cn 
姜珏 西安交通大学第二附属医院超声研究室, 陕西 西安 710004  
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中文摘要:
      目的 观察剪切波弹性成像(SWE)技术定量评价亚临床性甲状腺功能减退症(SCH)患者颈动脉弹性的价值,并与射频超声技术进行对比。方法 纳入84例SCH患者(观察组)及82名健康志愿者(对照组),以射频超声技术获取双侧颈动脉内-中膜厚度(IMT)、膨胀系数(DC)、顺应系数(CC)、α系数、β系数及脉搏波传导速度(PWV),以SWE技术测量平均、最大及最小弹性模量(MEmean、MEmax、MEmin),并比较各参数组间差异。采用线性回归评价各射频超声参数与MEmean间相关性。绘制受试者工作特征(ROC)曲线,计算曲线下面积(AUC),评价MEmean诊断SCH患者动脉弹性改变的效能。结果 观察组DC及CC均明显低于对照组(P均<0.05),α系数、β系数、PWV、MEmean及MEmax均明显高于对照组(P均<0.05)。α系数、β系数、PWV与MEmean均呈正相关(r=0.453、0.521、0.717,P均<0.05)。MEmean预测SCH患者动脉弹性改变的AUC为0.822,敏感度为76.2%,特异度为63.8%。结论 SWE技术可用于评价SCH患者颈动脉弹性改变。
英文摘要:
      Objective To observe the value of shear wave elastography (SWE) for quantitative evaluation on carotid elasticity in patients with subclinical hypothyroidism (SCH) compared with the radio frequency ultrasound technology. Methods A total of 84 cases of SCH patients (study group) and 82 healthy volunteers (control group) were enrolled. The intima-media thickness (IMT), distention coefficient (DC), compliance coefficient (CC), α coefficient, β coefficient and pulse wave velocity (PWV) of bilateral carotid artery were measured with the radio frequency ultrasound technology, while the mean elastic modulus of elasticity (MEmean), the maximum modulus of elasticity (MEmax) and minimum modulus of elasticity (MEmin) were measured with SWE. The above parameters were compared between groups. Linear regression was used to evaluate the correlation of the parameters and MEmean. The receiver operating characteristic (ROC) curves were drawn to calculate the area under the curve (AUC) for assess the efficacy of MEmean in evaluating elasticity in patients with SCH. Results DC and CC in study group were significantly lower than those in control group (all P<0.05), while α coefficient, β coefficient, PWV, MEmean and MEmax were significantly higher than those in control group (all P<0.05). MEmean was positively related to α coefficient, β coefficient and PWV (r=0.453, 0.521, 0.717, all P<0.05). The AUC of MEmean for predicting arterial elasticity changes of SCH patients was 0.822, with the sensitivity of 76.2% and the specificity of 63.8%. Conclusion SWE could quantitatively evaluate the changes of carotid elasticity in SCH patients.
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