| 任婧雅,董素贞.MRI定量评估胎儿脑体积[J].中国医学影像技术,2020,36(8):1121~1126 |
| MRI定量评估胎儿脑体积 |
| Quantitative assessment of fetal brain volume with MRI |
| 投稿时间：2019-10-17 修订日期：2020-07-02 |
| DOI：10.13929/j.issn.1003-3289.2020.08.001 |
| 中文关键词: 脑 体积 胎儿 磁共振成像 |
| 英文关键词:brain volume fetus magnetic resonance imaging |
| 基金项目:国家自然科学基金（81571628）、上海市自然科学基金（19ZR1476700）。 |
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| 中文摘要: |
| 目的 观察MRI定量脑体积评估胎儿大脑发育的价值。方法 对60例排除胎儿中枢神经系统异常或发育不良、孕周（GA）21~37周的单胎妊娠孕妇行胎儿MR检查，采用单次激发快速自旋回波（SSTSE）序列采集胎儿MRI，经后处理后手动分割大脑，测量胎儿三维脑体积指标颅腔内体积（ICV）、脑总容积（TBV）和脑脊液容积（CFV），计算大脑二维径线指标，包括大脑双顶径（BPD）、骨性双顶径（SBD）、枕额径（SOD）及头围（HC）。分析二维径线指标及三维脑体积指标与GA的相关性，并进行回归分析；观察三维脑体积指标与二维径线指标间的关系。结果 TBV（r=0.98）、ICV（r=0.97）、CFV（r=0.89）、BPD（r=0.96）、SBD（r=0.94）、SOD（r=0.96）、HC（r=0.96）均与GA呈高度正相关（P均<0.01）。TBV及ICV与二维径线各指标间均高度正相关（P均<0.01），HC与CFV间亦呈高度相关（P<0.01）。结论 MRI三维定量脑体积可较好评估GA 21~37周胎儿颅脑生长发育，有望为产前诊断胎儿脑疾病及研究其发病机制提供新的影像学手段。 |
| 英文摘要: |
| Objective To explore the value of MRI quantitative brain volume in evaluating fetal brain development. Methods A total of 60 single pregnant women with 21-37 weeks of gestation without central system lesion or dysplasia underwent fetal single-shot turbo spin echo (SSTSE) sequence MR scanning. The fetal brain images were post-processed, and then fetal three-dimensional brain volume indicators, including intracranial cavity volume (ICV), total brain volume (TBV) and cerebrospinal fluid volume (CFV) were manually measured. Meanwhile, two-dimensional diameter indexes of brain,i.e. brain biparietal diameter (BPD), skull biparietal diameter (SBD), skull fronto-occipitoal diameter (SOD) and head circumference (HC) were measured and calculated. The correlation of two-dimensional diameter indexes and three-dimensional brain volume indicators with gestational age (GA) were analyzed, and the corresponding regression analysis was carried out, respectively. The relationships between three-dimensional brain volume indicators and two-dimensional diametric indexes were analyzed. Results TBV (r=0.98), ICV (r=0.97), CFV (r=0.89), BPD (r=0.96), SBD (r=0.94), SOD (r=0.96) and HC (r=0.96) were all highly positively correlated with GA (all P<0.01), and the corresponding regression equations were obtained. There were high positive correlation among TBV, ICV and two-dimensional diametric indexes (all P<0.01)and strong correlation between HC and CFV (P<0.01). Conclusion MRI three-dimensional quantitative brain volume can be used to evaluate fetal brain development at 21-37 weeks of gestation, providing a new imaging method for prenatal diagnosis of fetal brain disease and study of pathogenesis. |
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