| 李培杰,张永高,高剑波,赵清霞.冠状动脉CTA观察HIV感染者冠状动脉易损斑块[J].中国医学影像技术,2020,36(3):391~395 |
| 冠状动脉CTA观察HIV感染者冠状动脉易损斑块 |
| Observation on vulnerable coronary plaques in HIV-infected patients based on coronary CTA |
| 投稿时间：2019-06-10 修订日期：2020-02-20 |
| DOI：10.13929/j.issn.1003-3289.2020.03.017 |
| 中文关键词: 冠状血管 易损斑块 人类免疫缺陷病毒 体层摄影术,X线计算机 |
| 英文关键词:coronary vessels vulnerable plaque HIV tomography,X-ray computer |
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| 中文摘要: |
| 目的 观察HIV感染者冠状动脉易损斑块是否与非HIV感染者存在差异，分析相关危险因素。方法 对167例HIV感染者（HIV感染组）及185例非感染者（非感染组）行冠状动脉CTA（CCTA），将存在≥2种高危形态学特征的斑块定义为易损斑块，对比分析2组患者冠状动脉易损斑块的类型、位置、发生率，以及HIV感染者冠状动脉易损斑块的相关危险因素。结果 2组患者基线临床资料无明显差异。2组最常见易损斑块类型均为低衰减斑块+正性重构，多位于前降支近段（S6）；HIV组≥1个冠状动脉节段出现易损斑块的发生率较非HIV组增加（34.73% vs 24.32%，P<0.05）。HIV组冠状动脉易损斑块与抗逆转录病毒治疗（ART）药物治疗时间独立相关[OR=1.29，95%CI（1.04，1.59），P=0.02]。结论 HIV感染者冠状动脉易损斑块发生率较非感染者增加；ART药物治疗可能是HIV感染者出现冠状动脉易损斑块的独立危险因素。 |
| 英文摘要: |
| Objective To explore whether vulnerable coronary plaques in HIV-infected patients are different with those in non-HIV-infected ones, and to analyze the relative risk factors. Methods A total of 167 HIV-infected patients (HIV-infected group) and 185 non-HIV-infected patients(non-HIV-infected group) who underwent coronary CTA (CCTA) were collected. Vulnerable plaques were defined as those with two or more high-risk morphological features. The type, location and incidence of vulnerable coronary plaques were analyzed and compared between 2 groups, and the risk factors of vulnerable coronary plaques in HIV-infected patients were analyzed. Results There was no significant difference of baseline clinical data between the two groups. The most common types of vulnerable coronary plaques in 2 groups were both low attenuation plaques+positive remodeling, most located in the proximal segment of left anterior descending artery (segment 6). The incidence of vulnerable coronary plaques ≥ 1 coronary segments in HIV-infected patients was higher than that in non-HIV-infected patients (34.73% vs 24.32%,P<0.05). Vulnerable coronary plaques in HIV-infected patients were independently correlated with the duration of antiretroviral therapy (ART) drug (OR=1.29, 95%CI[1.04,1.59], P=0.02). Conclusion The incidence of vulnerable coronary plaques in HIV-infected patients was higher than that in non-HIV-infected patients. ART drug may be an independent risk factor for coronary plaque vulnerability in HIV-infected patients. |
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