| 夏亭亭,尤晓婷,梁嘉敏,郑吴熙,邓恩昕,李靖煦,刘远明,关玉宝.定量CT对比观察轻-中度慢性阻塞性肺疾病及哮喘[J].中国医学影像技术,2020,36(3):345~349 |
| 定量CT对比观察轻-中度慢性阻塞性肺疾病及哮喘 |
| Comparison of mild-to-moderate chronic obstructive pulmonary disease and asthma with quantitative CT |
| 投稿时间：2019-06-29 修订日期：2019-07-26 |
| DOI：10.13929/j.issn.1003-3289.2020.03.005 |
| 中文关键词: 肺疾病,慢性阻塞性 哮喘 气道重塑 体层摄影术,X线计算机 |
| 英文关键词:pulmonary disease,chronic obstructive asthma airway remodeling tomography,X-ray computed |
| 基金项目:广东省科技计划项目（2017A040405065）、深圳市海外高层次人才创新创业专项资金（KQTD2017033110081833）。 |
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| 中文摘要: |
| 目的 观察稳定期轻-中度慢性阻塞性肺疾病（COPD）与哮喘患者近端气道结构及CT肺功能的差异。方法 对30例轻-中度COPD患者（mtmCOPD组）、30例轻-中度哮喘患者（mtmAs组）及30名健康对照者（健康对照组）行低剂量呼吸双相CT扫描及定量分析，比较其近端气道参数、肺气肿及空气潴留指数的差异。结果 mtmCOPD组与mtmAs组近端气道平均管腔面积（LA）/体表面积（BSA）分别为（10.93±2.58）mm2/m2和（10.81±3.20）mm2/m2，均小于健康对照组的（12.56±2.98）mm2/m2，mtmAs组与健康对照组差异有统计学意义（P=0.04）；mtmCOPD组和mtmAs组平均管壁面积百分比（WA%）分别为（63.02±2.34）%和（63.85±2.48）%，均大于健康对照组的（61.55±3.54）%，mtmAs组与健康对照组差异有统计学意义（P<0.01）。mtmCOPD组呼吸双相VI-910（%）及VI-950（%）均大于健康对照组（P均<0.01），呼气相平均肺密度（MLD）绝对值、呼气相VI-856（%）及MLD E/I均大于健康对照组（P均<0.05）。mtmCOPD组与mtmAs组气道结构参数、肺气肿及空气潴留指数差异均无统计学意义（P均>0.05）。结论 轻-中度COPD及哮喘患者近端支气管管腔面积较健康对照者均有缩小，近端气道管壁面积百分比较健康对照者均有增大，且轻-中度哮喘患者更加明显。轻-中度COPD患者存在明显肺气肿及空气潴留。 |
| 英文摘要: |
| Objective To investigate the differences of proximal airway structure and CT pulmonary function between steady mild-to-moderate chronic obstructive pulmonary disease (COPD) and asthma patients. Methods Thirty patients with mild-to-moderate COPD (mtmCOPD group), 30 patients with mild-to-moderate asthma (mtmAs group) and 30 healthy controls (normal control group) underwent low-dose paired inspiratory and expiratory CT scans and quantitative analysis. The differences of airway parameters, emphysema index and air trapping index were analyzed among 3 groups.Results The mean lumen area (LA)/body surface area (BSA) of the proximal airway of both mtmCOPD group and mtmAs group ([10.93±2.58]mm2/m2,[10.81±3.20]mm2/m2) were lower than that of normal control group ([12.56±2.98]mm2/m2), and statistically significant difference was found between mtmAs group and normal control group (P=0.04). The mean WA% of both mtmCOPD group and mtmAs group ([63.02±2.34]%,[63.85±2.48]%) were higher than that of normal control group ([61.55±3.54]%), while statistically significant difference was observed between mtmAs group and normal control group (P<0.01). The paired inspiratory and expiratory VI-910 (%) and VI-950 (%) of mild-to-moderate COPD were higher than those of healthy controls (all P<0.01). The expiratory absolute value of mean lung density (MLD), expiratory VI-856 (%) and MLD E/I of mtmCOPD group were also higher than those of normal control group (all P<0.05). There was no significant difference in airway structural parameters, emphysema nor air trapping index between mtmCOPD group and mtmAs group.Conclusion The lumen area of proximal bronchus of mild-to-moderate COPD and asthma patients were both smaller than that of healthy controls to a certain extent. Meanwhile, their percentage of proximal airway wall area were both larger than that of healthy controls, which were more obviously in patients with mild-to-moderate asthma. There were obvious emphysema and air trapping in mild-to-moderate COPD patients than in healthy subjects. |
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