曹宪宪,高小燕,于楠,师美娟,魏霞,金晨望,郭佑民.呼气相CT定量分析COPD患者肺血管[J].中国医学影像技术,2020,36(3):335~339
呼气相CT定量分析COPD患者肺血管
Expiratory CT in quantitative analysis of pulmonary vessels in COPD patients
投稿时间:2019-06-27  修订日期:2019-12-03
DOI:10.13929/j.issn.1003-3289.2020.03.003
中文关键词:  肺疾病,慢性阻塞性  血管  体层摄影术,X线计算机
英文关键词:pulmonary disease,chronic obstructive  blood vessels  tomography,X-ray computed
基金项目:国家卫生和计划生育委员会公益性行业科研专项基金(201402013)。
作者单位E-mail
曹宪宪 西安交通大学第一附属医院医学影像科, 陕西 西安 710061  
高小燕 西安交通大学第一附属医院医学影像科, 陕西 西安 710061  
于楠 陕西省中医药大学附属医院影像科, 陕西 咸阳 712000  
师美娟 西安交通大学医学院第二附属医院影像科, 陕西 西安 710004  
魏霞 西安市第九医院呼吸内科, 陕西 西安 710054  
金晨望 西安交通大学第一附属医院医学影像科, 陕西 西安 710061 jcw76@163.com 
郭佑民 西安交通大学第一附属医院医学影像科, 陕西 西安 710061  
摘要点击次数: 1814
全文下载次数: 595
中文摘要:
      目的 采用双气相CT扫描定量分析慢性阻塞性肺疾病(COPD)患者肺内血管体积(IPVV),观察呼气相CT定量肺血管对COPD患者的应用价值。方法 收集89例接受双气相CT扫描及肺功能检查(PFT)的COPD患者,定量测量双气相CT扫描IPVV。采用PearsonSpearman相关系数评估双气相IPVV与PFT结果的相关性,以Steiger Z检验分析相关系数。结果 全肺(WL)及各肺叶吸气相IPVV与第1秒用力呼气容积(FEV1)/用力肺活量(FVC)均呈负相关(r=-0.22~-0.36,P<0.05),IPVV和FEV1实测值与预计值的百分比(FEV1%)仅在右肺中叶(RML)及左肺下叶(LLL)呈负相关(r=-0.25及r=-0.23,P均<0.05);呼气相IPVV与FEV1%呈负相关(r=-0.20~-0.36,P<0.05),与FEV1/FVC呈负相关(r=-0.24~-0.39,P<0.05)。呼吸状态下IPVV变化与FEV1%呈正相关(r=0.31~0.46,P<0.01)。结论 双气相CT可定量评估COPD患者IPVV及呼吸状态下肺血管变化量,呼气相CT定量分析肺血管可为评估COPD呼气气流阻塞程度提供更多有效信息,为进一步观察COPD相关肺动脉高压的肺血管改变提供新的途径。
英文摘要:
      Objective To observe intrapulmonary vascular volume (IPVV) in chronic obstructive pulmonary disease (COPD) patients with double gas phase CT examination, so as to investigate the application value of expiratory phase CT in assessing pulmonary vascular alterations in COPD patients. Methods Totally 89 patients with COPD were retrospectively collected who underwent double gas phase CT examination and pulmonary function test (PFT). Pearson or Spearman correlation test was used to analyze correlations of IPVV and PFT results, and Steiger's Z test was used to explore the differences of correlation coefficients. Results In inspiratory scan, there was negative correlation between IPVV and forced expiratory volume in one second (FEV1)/forced vital capacity (FVC)in whole lung (WL)and all lobes (r=-0.22—-0.36, P<0.05),and there was negative correlation between IPVV and FEV1% only at right middle lobe (RML) and left lower lobe (LLL)(r=-0.25, -0.23, both P<0.05).In expiratory scan, IPVV was negatively correlated with FEV1% (r=-0.20—-0.36, P<0.05) and FEV1/FVC (r=-0.24—-0.39, P<0.05). Changes of IPVV under respiratory state were positively correlated with FEV1% (r=0.31-0.46, P<0.01). Conclusion Dual-gas phase CT can be used to quantitatively evaluate IPVV and changes of IPVV in COPD patients, while expiratory CT can provide more information for assessing degree of expiratory airflow obstruction in COPD, therefore providing a new approach for further observation of pulmonary vascular changes in COPD related pulmonary hypertension.
查看全文  查看/发表评论  下载PDF阅读器