| 刘丽娟,索文超.急性呼吸窘迫综合征患者下呼吸道重力依赖区气道关闭数值模拟[J].中国医学影像技术,2019,35(11):1722~1726 |
| 急性呼吸窘迫综合征患者下呼吸道重力依赖区气道关闭数值模拟 |
| Numerical simulation of airway closure in dependent regions of lower respiratory tract in acute respiratory distress syndrome patients |
| 投稿时间：2019-04-17 修订日期：2019-09-04 |
| DOI：10.13929/j.1003-3289.201904125 |
| 中文关键词: 呼吸窘迫综合征 成人 计算流体力学 重力依赖区 气道关闭 |
| 英文关键词:respiratory distress syndrome adult computational fluid dynamics dependent regions airway closure |
| 基金项目: |
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| 中文摘要: |
| 为了研究急性呼吸窘迫综合征（ARDS）患者下呼吸道重力依赖区气流特性的变化情况，基于CT影像建立真实人体下呼吸道三维模型，确定重力依赖区气道关闭位置，利用CFD技术对下呼吸道内气体进行瞬态数值模拟，得到了部分气道关闭后下呼吸道内空气流速、表面压力、壁面剪切应力等参数的变化趋势，理解了ARDS发生发展的病理生理变化，从而指导机械通气策略，避免呼吸机相关肺损伤的发生。 |
| 英文摘要: |
| In order to study the changes of airflow characteristics in dependent regions of lower respiratory tract in patients with acute respiratory distress syndrome (ARDS), a three-dimensional model of human lower respiratory tract was established based on CT images, and the positions of airway closure in dependent regions were selected. The transient airflow in lower respiratory tract was numerically simulated based on computational fluid dynamics (CFD) technology. The variation trends of airflow velocity, surface pressure and wall shear stress in lower respiratory tract after partial airway closure were obtained. The pathophysiological changes in the development of ARDS were understood, which could guide the strategy of mechanical ventilation and avoid the occurrence of ventilator-associated lung injury. |
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