卜姗姗,肖江喜,朱颖,王朝霞.杜氏肌营养不良与贝氏肌营养不良常规MRI的对比研究[J].中国医学影像技术,2019,35(11):1717~1721
杜氏肌营养不良与贝氏肌营养不良常规MRI的对比研究
Comparative study of conventional MRI between Duchenne muscular dystrophy and Becker muscular dystrophy
投稿时间:2019-03-22  修订日期:2019-09-18
DOI:10.13929/j.1003-3289.201903166
中文关键词:  杜氏肌营养不良  贝氏肌营养不良  磁共振成像
英文关键词:Duchenne muscular dystrophy  Becker muscular dystrophy  magnetic resonance imaging
基金项目:
作者单位E-mail
卜姗姗 北京大学第一医院医学影像科, 北京 100034  
肖江喜 北京大学第一医院医学影像科, 北京 100034 cjr.xiaojiangxi@vip.163.com 
朱颖 北京大学第一医院医学影像科, 北京 100034  
王朝霞 北京大学第一医院神经内科, 北京 100034  
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中文摘要:
      目的 探讨常规MRI鉴别诊断杜氏肌营养不良(DMD)和贝氏肌营养不良(BMD)的价值。方法 回顾性分析经临床确诊为抗肌萎缩蛋白病697例患者的臀部及大腿肌肉影像学资料,比较DMD与BMD影像学征象的异同。结果 DMD与BMD患者肌肉脂肪浸润的分布规律一致,DMD总体脂肪浸润程度高于BMD(P=0.034),且以臀大肌、股直肌、缝匠肌为著;肌肉总体水肿程度差异无统计学意义(P=0.065),但DMD大腿后群肌肉及缝匠肌的水肿明显高于BMD。DMD与BMD患者肌肉萎缩及肥大的选择性受累规律一致,BMD股外侧肌、股中间肌、股内侧肌、半膜肌及股二头肌长头萎缩频率明显高于DMD(P<0.05);DMD与BMD患者肌肉的肥大改变差异无统计学意义(P>0.05)。结论 常规MRI可鉴别诊断DMD与BMD。
英文摘要:
      Objective To investigate the value of conventional MRI in differential diagnosis of Duchenne muscular dystrophy (DMD) and Becker muscular dystrophy (BMD). Methods The imaging data of the hip and thigh muscles of 697 patients with dystrophinopathy were retrospectively analyzed, and the similarities and differences of signs between DMD and BMD were compared. Results The distribution of muscle fat infiltration in DMD and BMD patients was consistent, the total fat infiltration degree of DMD patients was higher than BMD patients (P=0.034), with the most obvious gluteus maximus, rectus femoris and sartorius; there was no significant difference in the degree of total muscle edema (P=0.065), however, the edema of the posterior thigh and sartorius of DMD was significantly higher than that of BMD. The selective involvement of muscle atrophy and hypertrophy was consistent between DMD and BMD patients, the frequency of atrophy of BMD lateral femoris, middle femoris, medial femoris, Semimembranosus and long head of biceps was significantly higher than that of DMD (P<0.05); there was no significant difference in muscle hypertrophy between the DMD and BMD (P>0.05). Conclusion Conventional MRI can differentiate DMD from BMD.
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