| 胡琴,翟建,吴雅琳,张政,程晓光.基于定量CT分析不同性别腰椎骨密度和血脂的相关性[J].中国医学影像技术,2019,35(9):1396~1399 |
| 基于定量CT分析不同性别腰椎骨密度和血脂的相关性 |
| Analysis of correlation of blood lipid and lumbar spine bone mineral density with different genders based on quantitative CT |
| 投稿时间：2019-03-08 修订日期：2019-06-28 |
| DOI：10.13929/j.1003-3289.201903054 |
| 中文关键词: 腰椎 骨密度 血脂 体层摄影术,X线计算机 定量分析 |
| 英文关键词:lumbar vertebrae bone density blood lipids tomography, X-ray computed quantitative analysis |
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| 摘要点击次数: 2020 |
| 全文下载次数: 600 |
| 中文摘要: |
| 目的 采用定量CT（QCT）测量腰椎骨密度（BMD），探讨不同性别腰椎BMD与血脂的相关性。方法 选取670名接受体检的中老年人，男341名，女329名，计算体质量指数（BMI）；空腹采集静脉血检测总胆固醇（TC）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）及低密度脂蛋白胆固醇（LDL-C）；使用QCT进行腰椎BMD测量，根据其结果分为骨量正常组、骨量减低组及骨质疏松组，分析3组不同性别腰椎BMD的差异及腰椎BMD与各血脂参数的相关性。以腰椎BMD为因变量，男性和女性差异有统计学意义的参数为自变量，进行多元线性回归分析。结果 男性骨量减低组TC和LDL-C均高于骨量正常组（P均<0.05）；女性骨质疏松组及骨量减低组TC高于骨量正常组，骨量减低组LDL-C高于骨量正常组（P均<0.05）。男性腰椎BMD与年龄、BMI及HDL-C均呈负相关（P均<0.05），女性腰椎BMD与年龄、TC、TG及LDL-C均呈负相关（P均<0.05）。多元线性回归结果显示年龄是导致中老年人腰椎BMD下降的危险性因素。结论 血脂异常与中老年腰椎BMD下降存在相关性，年龄是导致中老年人腰椎BMD下降的危险性因素。 |
| 英文摘要: |
| Objective To analyze the correlation between lumbar spine bone mineral density (BMD) and blood lipids in different genders by measuring lumbar spine BMD using quantitative CT (QCT). Methods Totally 670 subjects who underwent physical examinations were enrolled, including 341 males and 329 females, and their body mass index (BMI) were calculated. Fasting venous blood test for total cholesterol (TC), triglyceride (TG), high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) were performed. QCT was used to measure lumbar spine BMD. According to the results, the subjects were then divided into normal bone mass group, bone mass reduction group and osteoporosis group for each gender, and the differences of lumbar spine BMD of 3 groups for different genders and the correlation between lumbar spine BMD and various lipid parameters were analyzed. Taken lumbar spine BMD as the dependent variable, the parameters with statistically significant differences of male and female as independent variables, multiple linear regression analysis was performed. Results In males, TC and LDL-C in the bone mass reduction group were higher than those in the normal bone mass group (both P<0.05). In females, TC in the osteoporosis group and the bone mass reduction group were higher than that in normal bone mass group, and LDL-C in the bone mass reduction group was higher than that in normal bone mass group (all P<0.05). There was negative correlation between BMD and age, BMI and HDL-C in males (all P<0.05). Female lumbar spine BMD was negatively correlated with age, TC, TG and LDL-C (all P<0.05). Multiple linear regression results showed that age was a risk factor for the decline of lumbar spine BMD in middle-aged and elderly people. Conclusion There is correlation between dyslipidemia and the decrease of lumbar spine BMD in middle-aged and elderly people. Age is a risk factor for the decrease of lumbar spine BMD in middle-aged and elderly people. |
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