| 蔡清,林琳,汪洋,张弢,于扬,沈晶,伍建林.基于1H-MRS联合DTI定量检测2型糖尿病患者后扣带回损伤及其与认知功能的相关性[J].中国医学影像技术,2019,35(6):812~817 |
| 基于1H-MRS联合DTI定量检测2型糖尿病患者后扣带回损伤及其与认知功能的相关性 |
| Quantitative detection of posterior cingulate gyrus injuries and correlation with cognitive function in patients with type 2 diabetes mellitus based on 1H-MRS combined with DTI |
| 投稿时间：2018-10-20 修订日期：2019-04-17 |
| DOI：10.13929/j.1003-3289.201810110 |
| 中文关键词: 糖尿病,2型 扣带回 扩散张量成像 磁共振波谱学 |
| 英文关键词:diabetes mellitus, type 2 gyrus cinguli diffusion tensor imaging magnetic resonance spectroscopy |
| 基金项目:国家自然科学基金（81371526）、辽宁省自然科学基金（201602040）。 |
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| 中文摘要: |
| 目的 联合运用1H-MRS和DTI技术检测和评估2型糖尿病（T2DM）患者后扣带回（PCC）脑微结构损伤及脑代谢物异常改变，探讨其与认知功能障碍的相关性。方法 对43例T2DM患者[21例伴认知功能障碍（T2DM+CD组）、22例不伴认知功能障碍（T2DM组）]和23名健康志愿者（HC组）PCC进行单体素MRS及DTI检查，计算各代谢物波峰曲线下面积比值及各向异性分数（FA）、平均弥散率（MD），并与认知功能指标进行相关性分析。结果 T2DM+CD组PCC脑区肌醇/肌酸（mI/Cr）值高于T2DM和HC组，谷氨酸复合物/肌酸（Glx/Cr）低于T2DM和HC组（P均<0.05）；Glx/Cr与蒙特利尔认知评估量表（MoCA）评分呈正相关（r=0.59，P<0.01）。T2DM+CD组全脑及PCC脑区FA值低于T2DM和HC组，MD值高于T2DM和HC组（P均<0.05）；FA值与MoCA评分呈正相关（r=0.57，P=0.01）。结论 以PCC为兴趣区联合采用1H-MRS与DTI技术可定量反映T2DM引起认知功能损伤的神经病理学基础，有望成为早期预警的临床指标。 |
| 英文摘要: |
| Objective To detect and evaluate brain metabolism abnormalities and white matter changes of posterior cingulate cortex (PCC) in type 2 diabetes mellitus (T2DM) patients with 1H-MRS combined with DTI, and to explore the correlation between the changes and cognitive impairment. Methods Single-voxel 1H-MRS and DTI in PCC were performed in 43 patients with T2DM (21 with cognitive impairment[T2DM+CD group], 22 without cognitive impairment[T2DM group]) and 23 healthy volunteers (HC group). The integral value of related crest area and fractional anisotropy (FA), mean diffusivity (MD) values were calculated, and their correlation with cognitive function indicators were analyzed. Results The value of myo-inositol/creatine (mI/Cr) in PCC region of T2DM+CD group was higher than that of T2DM and HC groups, and the value of glutamate+glutamine/creatine (Glx/Cr) value was lower than that of T2DM and HC groups (all P<0.05). Glx/Cr was significantly positively correlated with Montreal cognitive assessment score (MoCA; r=0.59, P<0.01). FA values in the whole brain and PCC regions of T2DM+CD group were lower than those of T2DM and HC groups, and the MD values were higher than those of T2DM and HC groups (all P<0.05). FA value was significantly positively correlated with the score of MoCA (r=0.57, P=0.01). Conclusion The combination of 1H-MRS and DTI with PCC as ROI can be used to quantitatively reflect and mutually confirm the neuropathological basis of cognitive impairment induced by T2DM, which is expected to be a clinical indicator of early warning. |
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