| 吴奕君,陈文,徐霖,张涛.动脉自旋标记成像在终末期肾病认知障碍中的应用进展[J].中国医学影像技术,2019,35(5):778~781 |
| 动脉自旋标记成像在终末期肾病认知障碍中的应用进展 |
| Progresses of arterial spin labeling MRI in end-stage renal disease patients with cognitive impairment |
| 投稿时间：2018-11-27 修订日期：2019-03-07 |
| DOI：10.13929/j.1003-3289.201811146 |
| 中文关键词: 肾功能衰竭,慢性 认知功能障碍 动脉自旋标记 脑血流量 |
| 英文关键词:kidney failure, chronic cognitive dysfunction arterial spin labeling cerebral blood flow |
| 基金项目:湖北省教育厅科学研究计划项目（B2018115）。 |
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| 中文摘要: |
| 认知障碍是终末期肾病患者常见的中枢神经系统并发症之一，脑灌注异常被认为与认知功能改变有关。动脉自旋标记成像作为一种无创、可重复操作、无需对比剂的MR灌注成像技术，可不受血脑屏障的影响而定量评估脑血流量情况，在神经退行性疾病中的应用逐年增多。本文对动脉自旋标记成像在终末期肾病认知障碍中的应用进展进行综述。 |
| 英文摘要: |
| Cognitive impairment is one of the common neurological complications in end-stage renal disease (ESRD) patients and associates with abnormal cerebral perfusion. Arterial spin labeling (ASL) is a non-invasive and easily repeatable MRI perfusion technique without the use of contrast agent. ASL can quantitively measure the cerebral blood flow and is not influenced by break down of the blood-brain barrier, which makes ASL rapidly expands applications in neurodegenerative diseases. The clinical applications of ASL MRI in ESRD patients with cognitive dysfunction were reviewed in this article. |
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