| 张艳,杜方雪,冯宁,高硕辰.应用7关节超声评分评价类风湿关节炎达标治疗[J].中国医学影像技术,2019,35(5):745~749 |
| 应用7关节超声评分评价类风湿关节炎达标治疗 |
| Application of 7-joint ultrasound score in evaluation on treat-to-target of rheumatoid arthritis |
| 投稿时间：2018-11-15 修订日期：2019-03-01 |
| DOI：10.13929/j.1003-3289.201811079 |
| 中文关键词: 关节炎,类风湿 超声检查 达标治疗 7关节超声评分 |
| 英文关键词:arthritis, rheumatoid ultrasonography treat-to-target 7-joint ultrasound score |
| 基金项目:河南省医学科技攻关计划项目（201602066）。 |
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| 中文摘要: |
| 目的 探讨7关节超声评分在类风湿关节炎达标治疗中的应用价值。方法 收集活动期40例类风湿关节炎患者，遵循临床达标治疗原则，分析治疗前后28关节疾病活动度（DAS28）、滑膜炎、肌腱腱鞘炎及7关节超声评分的变化，并对滑膜炎、腱鞘炎及7关节超声评分变化量与DAS28变化量行相关性分析。结果 与治疗前相比，类风湿关节炎患者治疗后DAS28、滑膜炎、肌腱腱鞘炎及7关节超声评分均减低，差异均有统计学意义（P均<0.001）；治疗前后骨侵蚀差异无统计学意义（P=0.317）。治疗前后滑膜炎、肌腱腱鞘炎及7关节超声评分变化量与DAS28变化量均呈弱正相关（rs=0.363、0.318、0.317，P=0.021、0.045、0.047）。结论 7关节超声评分可为评价类风湿关节炎达标治疗效果提供参考，但不推荐仅以超声缓解作为达标治疗的检测指标。 |
| 英文摘要: |
| Objective To explore the application value of 7-joint ultrasound score in the treat-to-target of rheumatoid arthritis. Methods Totally 40 patients with rheumatoid arthritis in active stage were enrolled. The changes of disease activity score of 28 joints (DAS28), synovitis, tenosynovitis and 7-joint ultrasound score before and after treatment were analyzed in accordance with the principles of clinical standard treatment, and the correlation of changes of synovitis, tenosynovitis, 7-joint ultrasound score and changes of DAS28 were analyzed. Results Compared with those before treatment, DAS28, synovitis, tenosynovitis and 7-joint ultrasound score decreased significantly after escalation therapy (all P<0.001), but changes in bone erosion were not statistically significant (P=0.317). The changes of synovitis, tenosynovitis, 7-joint ultrasound score and DAS28 showed relatively weak correlation (rs=0.363, 0.318, 0.317, P=0.021, 0.045, 0.047). Conclusion 7-joint ultrasound score can be used to detect changes of disease activity of rheumatoid arthritis, but not yet be advocated as testing index for treat-to-target escalation. |
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