| 欧阳丽蓉,廖伟华,周高峰,刘孟辉,张友明,卓沛,沈璐.基于中国人脑图谱Chinese2020配准的阿尔茨海默病患者静息态fMRI[J].中国医学影像技术,2019,35(1):9~14 |
| 基于中国人脑图谱Chinese2020配准的阿尔茨海默病患者静息态fMRI |
| Resting-state fMRI analysis based on Chinese brain template Chinese2020 in patients with Alzheimer disease |
| 投稿时间：2018-09-10 修订日期：2018-11-26 |
| DOI：10.13929/j.1003-3289.201809047 |
| 中文关键词: 阿尔茨海默病 磁共振成像 低频振幅 局部一致性 中国人脑图谱 |
| 英文关键词:Alzheimer disease magnetic resonance imaging amplitude of low-frequency fluctuation regional homogeneity Chinese brain template |
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| 中文摘要: |
| 目的 探讨基于中国人脑图谱Chinese2020配准的静息态功能MR数据分析在阿尔茨海默病（AD）患者中的应用价值。方法 收集12例AD患者（AD组）和17名健康志愿者（正常对照组），基于中国人脑图谱Chinese2020和传统标准脑图谱ICBM152配准对静息态数据进行全脑分析，运用低频振幅（ALFF）和局部一致性（ReHo）分析方法，评估AD患者脑局部神经元自发活动的变化，并比较基于2种脑图谱配准计算的AD患者ALFF和ReHo差异性脑区的分布。结果 基于2种脑图谱的数据分析均发现，与正常对照组比较，AD组右侧颞上回、右侧楔前叶和右侧角回ALFF值减低，左侧小脑、左侧颞极、颞上回和颞中回ALFF升高（P均<0.05）；AD组左侧颞中回、右侧颞下回、左侧三角部额下回和左侧楔叶ReHo值减低，左侧小脑ReHo值升高（P均<0.05）。基于Chinese2020分析获得的相同的差异脑区平均灰质占比[ALFF：（38.85±17.88）%；ReHo：（54.69±13.28）%]高于基于传统脑图谱ICBM152分析[ALFF：（33.75±14.70）%；ReHo：（45.66±12.35）%]，但差异无统计学意义（P=0.68、0.21）。结论 基于中国人脑图谱Chinese2020配准的静息态功能磁共振数据分析在检测中国AD患者的局部神经元自发活动方面较传统的西方人脑图谱更准确。 |
| 英文摘要: |
| Objective To explore the application value of Chinese brain template Chinese2020 in resting-state functional magnetic resonance imaging (rs-fMRI) data analysis of Chinese Alzheimer disease (AD) patients. Methods Twelve Chinese AD patients (AD group) and 17 healthy volunteers (control group) were collected. Then rs-fMRI data were registered to the Chinese brain template Chinese2020 and traditional standard brain template ICBM152, respectively. Whole brain analysis was performed to explore the regional spontaneous neuronal activity alterations in AD patients, in which amplitude of low-frequency fluctuation (ALFF) and regional homogeneity (ReHo) were extracted as indicators. The distribution pattern of brain regions with significant differences obtained from the data analysis based on the two templates was compared respectively. Results The results from both templates showed that ALFF in AD group decreased in right superior temporal gyrus, right precuneus and right angular gyrus while increased in left cerebellum, left temporal pole, superior temporal gyrus and left middle temporal gyrus (all P<0.05), and ReHo in AD group decreased in left middle temporal gyrus, right inferior temporal gyrus, left trigonometric frontalis inferior gyrus and left cuneus, while increased in left cerebellum (all P<0.05) compared with in control group. In the analysis based on Chinese brain template Chinese2020, the average of the gray matter volume percentage within the activated areas (ALFF:[38.85±17.88]%, ReHo:[54.69±13.28]%) were higher than those based on traditional standard brain template ICBM152(ALFF:[33.75±14.70]%, ReHo:[45.66±12.35]%), but without difference (P=0.68, 0.21). Conclusion In rs-fMRI study of Chinese AD, analysis based on Chinese brain template Chinese2020 may provide more accurate information than on conventional westerner brain template. |
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