| 李灿,徐白萱,张锦明,刘家金,富丽萍.早期相11C-PIB PET显像探讨阿尔茨海默病患者脑功能网络改变[J].中国医学影像技术,2018,34(11):1621~1626 |
| 早期相11C-PIB PET显像探讨阿尔茨海默病患者脑功能网络改变 |
| Early-phase 11C-PIB PET imaging in identifying brain network alterations in Alzheimer disease |
| 投稿时间：2018-07-13 修订日期：2018-09-10 |
| DOI：10.13929/j.1003-3289.201807097 |
| 中文关键词: 阿尔茨海默病 认知障碍 体层摄影术,发射型计算机 11C-匹兹堡化合物 氟脱氧葡萄糖F18 |
| 英文关键词:Alzheimer disease Cognition disorders Tomography, emission-computed 11C-Pittsburgh compound B Fludeoxyglucose F 18 |
| 基金项目:中国博士后科学基金（20090461433、2013M542515）。 |
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| 摘要点击次数: 2013 |
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| 中文摘要: |
| 目的 探讨阿尔茨海默病（AD）和轻度认知功能障碍（MCI）患者11C-匹兹堡化合物（11C-pPIB）脑灌注网络改变。方法 对14例AD（AD组）、12例MCI（MCI组）和14名认知功能正常志愿者（对照组）行18F-FDG及11C-PIB双示踪剂PET显像，采用平行独立成分分析法（pICA）计算11C-pPIB和18F-FDG数据中高度相关的脑网络，以双样本t检验比较AD组与对照组间和MCI组与对照组间18F-FDG低代谢与11C-pPIB低灌注的差异，获得组间有差异的脑区。结果 11C-pPIB获得的脑灌注网络与18F-FDG代谢网络高度相关（r=0.92），并与默认网络（DMN）存在空间重叠。与对照组比较，AD组18F-FDG低代谢区与11C-pPIB低灌注区存在空间重叠，包括颞上回、边缘叶/海马旁回、顶上小叶、后扣带回和前扣带回；MCI组18F-FDG的低代谢脑区位于右侧直回/眶额回、左侧后扣带回、右侧颞下回和右侧顶下小叶/颞上回，11C-pPIB低灌注脑区为右侧顶下小叶。结论 AD患者11C-pPIB低灌注脑区与18F-FDG低代谢高度相关，并与DMN存在空间重叠。11C-pPIB显像可为诊断AD提供与18F-FDG显像互补的信息。 |
| 英文摘要: |
| Objective To observe the brain network changes in patients with Alzheimer disease (AD) and mild cognitively impaired (MCI) using early-phase 11C-PIB (Pittsburgh compound B, pPIB) PET scan. Methods A total of 14 patients with AD (AD group), 12 patients with MCI (MCI group) and 12 healthy controls (control group) underwent 11C-PIB and 18F-FDG PET/CT scaning. The parallel independent component analysis (pICA) was used to calculate strong correlated brain networks between AD and MCI patients. The differences of hypometabolic FDG and low perfusion 11C-pPIB areas were compared among AD, MCI and control groups with two-sample t-test. Results The brain perfusion network derived from 11C-pPIB PET was strongly correlated with brain metabolic network derived from 18F-FDG PET (r=0.92), both co-localized with the default mode network (DMN). Particularly, compared with control group, a decreased 18F-FDG uptake was shown to correlate with a lower regional perfusion of 11C-pPIB in superior temporal gyrus, limbic lobe/parahippocampal gyrus, superior parietal lobule, anterior cingulate cortex and posterior cingulate cortex in AD group; in MCI group, 18F-FDG uptake decreased in the right rectal gyrus/orbit frontal cortex, left posterior cingulate cortex, right inferior temporal gyrus and right inferior parietal lobule/superior temporal gyrus, while hypoperfusion of 11C-pPIB was only detected in the right inferior parietal lobule. Conclusion There is strong relationship between hypometabolic 18F-FDG and low perfusion 11C-pPIB areas in AD patients, both co-localized with the DMN. 11C-pPIB can provide complementary information for 18F-FDG examination in AD. |
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