| 王化,叶兆祥.非小细胞肺癌CT特征与驱动基因突变相关性影像基因组学研究进展[J].中国医学影像技术,2018,34(6):940~944 |
| 非小细胞肺癌CT特征与驱动基因突变相关性影像基因组学研究进展 |
| Progresses of radiogenomics in association between CT features and driver gene mutations of non-small cell lung cancer |
| 投稿时间：2017-11-28 修订日期：2018-03-10 |
| DOI：10.13929/j.1003-3289.201711142 |
| 中文关键词: 癌,非小细胞肺 体层摄影术,X线计算机 突变 影像基因组学 |
| 英文关键词:Carcinoma, non-small cell lung Tomography, X-ray computed Mutation Radiogenomics |
| 基金项目:国家自然科学基金（81601492）。 |
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| 英文摘要: |
| Driver genes of non-small cell lung cancer (NSCLC) include EGFR, KRAS, BRAF, PIK3CA and ALK, etc. Obtaining precise molecular phenotype is the premise of target therapy. However, because of heterogeneity of NSCLC, the genetic mutations of the tumor may not be accurately obtained from small biopsy samples. As a routine modality for NSCLC, CT may comprehensively reflect the underlying pathophysiology and molecular biology of the tumors. Radiogenomics, which is focusing on defining relationships between image features (image phenotypes) and molecular markers (molecular phenotypes), has a broad prospect in the prediction of driver gene mutations of NSCLC. Progresses of radiogenomics in association between CT features and driver gene mutations of NSCLC were reviewed in this article. |
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