| 彭俊萍,江桂华,吕晓飞,田军章,苏欢欢,林楚岚,娄明武.慢性肝硬化患者神经认知损害与背侧丘脑代谢改变的相关性[J].中国医学影像技术,2018,34(6):822~825 |
| 慢性肝硬化患者神经认知损害与背侧丘脑代谢改变的相关性 |
| Correlation of neurocognitive impairment and metabolic changes of thalamus in patients with chronic liver cirrhosis |
| 投稿时间：2017-11-13 修订日期：2018-04-10 |
| DOI：10.13929/j.1003-3289.201711076 |
| 中文关键词: 肝炎,乙型,慢性 肝硬化 肝性脑病 丘脑 磁共振波谱 |
| 英文关键词:Hepatitis B, chronic Liver cirrhosis Hepatic encephalopathy Thalamus Magnetic resonance spectroscopy |
| 基金项目:中国博士后科学基金（2016M592479）。 |
|
| 摘要点击次数: 1813 |
| 全文下载次数: 633 |
| 中文摘要: |
| 目的 分析慢性乙型肝炎肝硬化者认知功能改变与背侧丘脑1H MRS改变的相关性。方法 收集慢性乙型肝炎肝硬化患者28例（肝硬化组）和同期健康体检者28名（对照组），分别进行神经心理学测试数字连接试验A （NCT-A）、数字符号试验（DST）和MRS检查；计算各代谢物，包括N-乙酰天门冬氨酸（NAA）、胆碱（Cho）、谷氨酰胺复合物（Glx）和肌醇（mI）的峰下面积与肌酸（Cr）峰下面积的比值（NAA/Cr、Cho/Cr、Glx/Cr及mI/Cr）。结果 与对照组比较，肝硬化组Cho/Cr、mI/Cr减小，Glx/Cr升高，NCT-A时间延长、DST得分减少（P均<0.001）。肝硬化组NCT-A时间与Cho/Cr、mI/Cr呈负相关（r=-0.477，P=0.001；r=-0.695，P<0.001），与Glx/Cr呈正相关（r=0.665，P<0.001）；DST得分与Cho/Cr、mI/Cr呈正相关（r=0.478，P=0.001；r=0.632，P<0.001），与Glx/Cr负相关（r=-0.572，P<0.001）。结论 慢性乙型肝炎肝硬化患者神经认知功能障碍可能与背侧丘脑内代谢改变相关。 |
| 英文摘要: |
| Objective To analyze the relationship of neurocognitive impairments and 1H MRS changes of the thalamus in patients with chronic hepatitis B virus-related cirrhosis (HBV-RC). Methods Totally 28 patients with HBV-RC (cirrhosis group) and 28 well-matched healthy subjects (control group) were enrolled. All subjects underwent number connection test A (NCT-A) and the digit symbol test (DST) before MRS scanning. The ratios of peak area to each metabolite, including N-acetylaminosuccinic acid (NAA), choline (Cho), glutamine and glutamate (Glx), myoinositol (mI) and creatine (Cr) were calculated, respectively. Results Compared with control group, patients in cirrhosis group showed lower Cho/Cr and mI/Cr, higher Glx/Cr, prolonged NCT-A time and decreased DST scores (all P<0.001). NCT-A completion time was negatively correlated with Cho/Cr and mI/Cr (r=-0.477, P=0.001; r=-0.695, P<0.001) and positively correlated with Glx/Cr (r=0.665, P<0.001). DST scores were positively correlated with Cho/Cr and mI/Cr (r=0.478, P=0.001; r=0.632, P<0.001), and negatively correlated with Glx/Cr (r=-0.572, P<0.001). Conclusion The neurocognitive impairments may be related to metabolic changes of the thalamus in patients with HBV-RC. |
| 查看全文 查看/发表评论 下载PDF阅读器 |
|
|
|
