| 江建芹,蔡荣芳,崔磊,尹剑兵,许一鸣,马航,何海艳.肺癌体素内不相干运动参数值测量的短期可重复性及影响因素[J].中国医学影像技术,2018,34(4):543~547 |
| 肺癌体素内不相干运动参数值测量的短期可重复性及影响因素 |
| Short-term reproducibility and impact factors of intravoxel incoherent motion parameters for lung cancer |
| 投稿时间：2017-07-27 修订日期：2018-01-25 |
| DOI：10.13929/j.1003-3289.201707142 |
| 中文关键词: 肺肿瘤 扩散磁共振成像 体素内不相干运动 可重复性,结果 |
| 英文关键词:Lung neoplasms Diffusion magnetic resonance imaging Intravoxel incoherent motion Reproducibility of results |
| 基金项目:江苏省2017年高层次卫生人才"六个一工程"拔尖人才项目（LGY2017037）、南通市科技局医技综合研究重点专项课题、盐城市医学科技发展计划项目（YK2017021）。 |
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| 中文摘要: |
| 目的 评估肺癌短期重复扫描体素内不相干运动（IVIM）参数值测量的短期可重复性及影响因素。方法 对38例肺癌患者进行2次自由呼吸IVIM成像（间隔0.5~1.0 h）。由2名测量者基于IVIM图像独立测量慢扩散参数（D）、快扩散系数（D*）及灌注分数（f）均值。采用配对样本t检验或Wilcoxon检验比较重复测量和重复扫描的误差。以组内相关系数（ICC）评价各参数值同一测量者和不同测量者的一致性和可重复性。采用变异系数（WCV）比较肺癌类型（周围型、中央型）、病变大小（≥ 2 cm、<2 cm）及位置（上、中、下肺野）对各参数值可重复性的影响。结果 所有参数2次测量的系统误差差异均无统计学意义（P均>0.05）。D*和f值的WCVs（19.88%~36.83%）明显高于D值（2.97%~4.62%）。D值在中央型肺癌及最大径< 2 cm病灶的WCVs较高，并自上肺野到下肺野WCV依次增加；f在中央型肺癌和最大径≥ 2 cm的WCVs较大；D*受肺癌类型、大小和位置的影响显著。结论 在肺癌的重复扫描中，D值可重复性好，而D*、f值的可重复性较差；肺癌类型、大小和位置是影响IVIM参数值的因素。 |
| 英文摘要: |
| Objective To prospectively evaluate the short-term test-retest reproducibility of intravoxel incoherent motion (IVIM) parameters for lung cancer, and to investigate its impact factors. Methods Thirty-eight lung cancer patients underwent twice free-breathing IVIM scanning (0.5-1.0 h interval). Two radiologists independently analyzed IVIM images to obtain true diffusion coefficient (D), pseudo-diffusion coefficient (D*) and perfusion fraction (f). All the parameters were compared between repeated measurements and scans. Intra-and inter-observer, test-retest reproducibility was assessed with interclass correlation coefficients (ICCs). The impact of lung cancer type (peripheral and central), size (the largest diameter ≥ 2 cm and <2 cm) and location (upper, mid, and lower lung field) on short-term reproducibility were compared by using coefficient of variations (WCVs). Results There was no significant difference between repeated measurements for all parameters (all P>0.05). All the parameters showed good intra-and inter-observer agreement. WCVs of D* and f (19.88%-36.83%) were higher than those of D (2.97%-4.62%). WCVs of D were higher for central lung cancer and the largest diameter <2 cm, and increasing from apical to lower zone. WCV of f was larger in the central lung cancer and the largest diameter ≥ 2 cm, while D* was greatly influenced by type, size and location of lung cancer. Conclusion The test-retest reproducibility of D is good, while of D* and f are poor in lung cancer. The type, size and location of lung cancers are the impact factors of IVIM parameters. |
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