| 张乐,孙洪赞,辛军,杜思瑶,张立欧,李可心.宫颈癌18F-FDG PET/CT标准化摄取值与血管内皮生长因子、水通道蛋白1表达及临床病理特征的相关性[J].中国医学影像技术,2018,34(2):260~264 |
| 宫颈癌18F-FDG PET/CT标准化摄取值与血管内皮生长因子、水通道蛋白1表达及临床病理特征的相关性 |
| Correlations of 18F-FDG PET/CT standardized uptake value, vascular endothelial growth factor, Aquaporin-1 level and clinicopathological features of cervical cancer |
| 投稿时间：2017-07-04 修订日期：2017-11-21 |
| DOI：10.13929/j.1003-3289.201707007 |
| 中文关键词: 宫颈肿瘤 正电子发射型体层摄影术 体层摄影术,X线计算机 血管内皮生长因子 水通道蛋白-1 |
| 英文关键词:Cervical neoplasms Positron-emission tomography Tomography, X-ray computed Vascular endothelial growth factor Aquaporin-1 |
| 基金项目:国家自然科学基金青年科学基金（81401438）、辽宁省教育厅科学研究一般项目（L2014308）、辽宁省教育厅重点实验室基础研究项目（LZ2015079）。 |
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| 中文摘要: |
| 目的 探讨宫颈癌18F-FDG PET/CT标准化摄取值（SUV）与血管内皮生长因子（VEGF）、水通道蛋白-1（AQP-1）表达水平及临床病理特征之间的相关性。方法 回顾性分析56例宫颈癌患者术前PET/CT影像资料，测量肿瘤平均标准化摄取值（SUVmean）、最大标准化摄取值（SUVmax）及标准化摄取值峰值（SUVpeak）。应用免疫组织化学方法检测宫颈癌组织的VEGF、AQP-1表达水平，分析SUV值与VEGF、AQP-1表达水平及临床病理特征间的相关性。结果 国际妇产科联合会（FIGO）不同分期间SUVmean、SUVpeak、VEGF、AQP-1表达水平差异均有统计学意义（P均< 0.05）；肿瘤最大径≥ 4 cm者SUVpeak和VEGF表达水平均高于最大径< 4 cm者（P均< 0.05）；浸润深度≥ 1/2宫颈肌壁者SUVpeak、VEGF和AQP-1表达水平均高于浸润深度< 1/2宫颈肌壁者（P均< 0.05）；有淋巴结转移者VEGF和AQP-1表达水平均高于无淋巴结转移者（P均< 0.05）。SUVpeak与VEGF（rs=0.529，P < 0.001）、AQP-1（rs=0.356，P=0.007）表达水平的相关性相对较高。结论 宫颈癌术前PET/CT SUVpeak值与临床病理特征有相关性，可用于指导制定宫颈癌个体化治疗方案。 |
| 英文摘要: |
| Objective To explore the correlations among standardized uptake value (SUV) and clinicopathological features of cervical cancers, and to observe the association among SUV and expression level of vascular endothelial growth factor (VEGF) and Aquaporin-1 (AQP-1). Methods PET/CT imaging data were analyzed retrospectively in 56 patients with cervical cancer before surgery. The mean SUV (SUVmean), maximum SUV (SUVmax) and peak SUV (SUVpeak) were measured, and immunohistochemical method was used to detect the expression of VEGF and AQP-1. The relationships of SUV and expression level of VEGF, AQP-1 and clinicopathological features were analyzed. Results SUVmean, SUVpeak and expression level of VEGF and AQP-1 were significantly different in different FIGO stages (all P<0.05). SUVpeak and expression level of VEGF in tumors with maximum diameter ≥ 4 cm were higher than those in patients with tumors maximum diameter <4 cm (both P <0.05). SUVpeak and expression level of VEGF and AQP-1 in tumors with cervical stromal invasion depth ≥ 1/2 were significantly higher than those with cervical stromal invasion depth <1/2 (all P<0.05). The expression level of VEGF and AQP-1 in patients with lymph node metastasis were higher than those without lymph node metastasis (both P <0.05). SUVpeak was correlated with expression level of VEGF (rs=0.529, P < 0.001) and AQP-1 (rs=0.356, P=0.007). Conclusion Preoperative SUVpeak of cervical cancer measured with PET/CT is correlated with clinicopathological features and can be used to guide individual treatment of patients with cervical cancer. |
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