洪居陆,李慧,申小明,卢瑞梁,贺小红,周新韩,高明勇.基于定量磁敏感成像的急性缺血性脑卒中磁化率分析[J].中国医学影像技术,2018,34(2):185~189
基于定量磁敏感成像的急性缺血性脑卒中磁化率分析
Analysis of magnetic susceptibility in acute cerebral ischemia using quantitative susceptibility mapping
投稿时间:2017-06-28  修订日期:2017-11-25
DOI:10.13929/j.1003-3289.201706151
中文关键词:  磁敏感成像  磁共振成像  磁化率  脑卒中
英文关键词:Susceptibility mapping  Magnetic resonance imaging  Magnetic susceptibility  Brain ischemia
基金项目:广东省医学科学技术研究基金(A2017231)、佛山市医学类科技攻关项目(2016AB002431)、佛山市医学重点专科培育项目(Fspy3-2015013)。
作者单位E-mail
洪居陆 佛山市第一人民医院 中山大学附属佛山医院医学影像科, 广东 佛山 528000  
李慧 佛山市第一人民医院 中山大学附属佛山医院肿瘤中心放疗科, 广东 佛山 528000  
申小明 佛山市第一人民医院 中山大学附属佛山医院医学影像科, 广东 佛山 528000  
卢瑞梁 佛山市第一人民医院 中山大学附属佛山医院医学影像科, 广东 佛山 528000  
贺小红 佛山市第一人民医院 中山大学附属佛山医院医学影像科, 广东 佛山 528000  
周新韩 佛山市第一人民医院 中山大学附属佛山医院医学影像科, 广东 佛山 528000  
高明勇 佛山市第一人民医院 中山大学附属佛山医院医学影像科, 广东 佛山 528000 gmyong163@163.com 
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中文摘要:
      目的 采用定量磁敏感成像(QSM)分析急性缺血性脑卒中(ACI)的磁化率变化。方法 对符合纳入标准的23例ACI患者行常规头颅MR和QSM扫描,通过工作站QSM软件行图像后处理,根据有无脑微出血灶(CMBs),将ACI分为CMBs组和无CMBs组。以DWI图为参考,于磁敏感图病灶处手工勾画ROI,包括皮层灰质(CGM)、皮层下白质(SWM)、尾状核(CA)、苍白球(GP)、壳核(PU)、丘脑(TH)、黑质(SN)、齿状核(DN)、桥脑(PO),获得病灶磁化率,并通过镜像方式获得对侧镜像区磁化率。对不同组别和ROIs分别与对侧镜像区的磁化率进行统计学分析。结果 CMBs组和无CMBs组病灶磁化率差异有统计学意义(Z=-3.297,P=0.001)。CMBs组病灶侧与对侧的磁化率差异有统计意义(Z=-3.296,P=0.001),无CMBs组病灶侧与对侧的磁化率差异无统计学意义(Z=-0.157,P=0.875)。根据ROI的位置,仅PO和CGM磁化率与对侧的差异有统计学意义(Z=-2.023、-3.130,P=0.043、0.002)。结论 QSM可定量分析ACI磁化率,发现CMBs,有助于指导治疗。
英文摘要:
      Objective To analyze the changes of susceptibility in acute cerebral ischemia (ACI) using quantitative susceptibility mapping (QSM). Methods Twenty-three patients with ACI who met the criteria underwent conventional brain MR and QSM scan, and the susceptibility maps were obtained with QSM post-processing software in image processing workstation. According to DWI images, ROIs were manually drawn on lesions of ACI to obtain magnetic susceptibility on susceptibility map, including cortical gray matter (CGM), subcortical white matter (SWM), caudate (CA), globus pallidus (GP), putamen (PU), thalamus (TH), substantia nigra (SN), dentate nucleus (DN) and pons (PO). Then magnetic susceptibility of contralateral position was obtained. According to whether cerebral microbleeds (CMBs) were observed, the ACI patients were divided into CMBs group and non-CMBs group. The magnetic susceptibility of groups and different ROIs of ACI and the contralateral area were compared statistically. Results There was significant difference in magnetic susceptibility between CMBs group and non-CMBs group (×10-9 ppd; Z=-3.297, P=0.001). The difference of magnetic susceptibility between the lesion side and the contralateral side (×10-9 ppd) was statistically significant in CMBs group (Z=-3.296, P=0.001), but not in non-CMBs group (contralateral side×10-9 ppd; Z=-0.157, P=0.875). According to the location of ROIs, magnetic susceptibility had statistical differences only in PO, CGM and contralateral side (Z=-2.023, -3.130, P=0.043, 0.002). Conclusion QSM can be used to quantitatively analyze magnetic susceptibility of ACI lesions and find CMBs, therefore is helpful to guiding treatment.
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