| 樊子健,张永波,鞠文萍,梁洁,李达,王现亮.MRS在非海马硬化颞叶癫痫患者中的应用[J].中国医学影像技术,2017,33(9):1326~1330 |
| MRS在非海马硬化颞叶癫痫患者中的应用 |
| MRS application in temporal lobe epilepsy without hippocampal sclerosis |
| 投稿时间：2016-11-24 修订日期：2017-06-19 |
| DOI：10.13929/j.1003-3289.201611125 |
| 中文关键词: 颞叶 癫痫 海马 磁共振波谱 |
| 英文关键词:Temporal lobe Epilepsy Hippocampus Magnetic resonance spectroscopy |
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| 中文摘要: |
| 目的 探讨MRS技术在非海马硬化颞叶癫痫患者中的应用价值。方法 回顾性分析于我院诊治为非海马硬化的单侧颞叶癫痫患者23例（病例组），选取年龄与之相匹配的20名正常志愿者作为对照组，行常规MR平扫及MRS检查，分析颞叶癫痫患者患侧海马、健侧海马及对照组海马N-乙酰天门冬氨酸（NAA）/肌酸（Cr）、胆碱（Cho）/Cr值的差异；同时评价病例组中接受手术治疗的11例患者的病理及手术结果。结果 病例组患侧海马NAA/Cr值较健侧海马（t=-7.97，P<0.001）及对照组海马降低（t=-9.96，P<0.001），病例组健侧海马NAA/Cr值与对照组比较差异无统计学意义（t=-1.21，P=0.12）。病例组患侧海马Cho/Cr与健侧（t=0.50，P=0.31）及对照组海马（t=-0.59，P=0.28）差异无统计学意义。11例行致痫侧颞叶切除患者的病理结果显示小范围少量的神经元损伤，神经胶质增生不明显。结论 MRS有助于临床对非海马硬化颞叶癫痫患者的致痫灶进行定侧及定位。 |
| 英文摘要: |
| Objective To investigate the application value of MRS in temporal lobe epilepsy (TLE) without hippocampal sclerosis. Methods A retrospective study was conducted in 23 unilateral TLE patients (TLE group) with absence of hippocampal sclerosis and 20 age-matched normal control subjects (control group). All of them underwent conventional MRI and MRS. N-acetyl aspartate (NAA)/creatine (Cr), choline (Cho)/Cr ratios of bilateral hippocampus in 2 groups were analyzed. Eleven of 23 patients underwent surgical treatment, pathological findings and surgical outcomes were evaluated. Results The NAA/Cr ratios of ipsilateral hippocampus significantly decreased compared with that in the contralateral hippocampus (t=-7.97, P<0.001) and the control group (t=-9.96, P<0.001). There was no significant difference between the contralateral hippocampus in patients and the control group (t=-1.21, P=0.12). The Cho/Cr ratios of ipsilateral hippocampus in TLE had no significant difference compared with contralateral hippocampus (t=0.50, P=0.31) and the control group (t=-0.59, P=0.28). The pathological findings of the 11 patients who underwent temporal lobe resection indicated small amounts of neuronal loss and unobvious gliosis. Conclusion MRS is helpful in clinical practice to lateralize and localize the epileptogenic foci in the absence of hippocampal sclerosis in patients with TLE. |
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