| 熊文娟,何来昌,谭永明,周福庆,曾献军,龚洪瀚,李志.经典三叉神经痛患者脑局部自发活动的静息态功能MRI[J].中国医学影像技术,2017,33(9):1321~1325 |
| 经典三叉神经痛患者脑局部自发活动的静息态功能MRI |
| Resting-state functional MRI of regional spontaneous brain activity in classical trigeminal neuralgia patients |
| 投稿时间：2016-11-09 修订日期：2017-06-22 |
| DOI：10.13929/j.1003-3289.201611055 |
| 中文关键词: 三叉神经痛 磁共振成像 局部自发活动 |
| 英文关键词:Trigeminal neuralgia Magnetic resonance imaging Regional spontaneous activity |
| 基金项目:国家自然科学基金（81460329）、江西省自然科学基金（2013ZBAB205007）。 |
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| 中文摘要: |
| 目的 观察经典三叉神经痛（CTN）患者静息状态下脑局部自发活动的改变。方法 对27例CTN患者（CTN组）和27名健康对照者（对照组）行静息态脑功能MRI数据采集，采用局部一致性（ReHo）数据分析方法获得CTN组ReHo差异脑区，并对组间差异脑区ReHo值分别与患者视觉模拟评分（VAS）和病程行相关性分析。结果 与对照组比较（P<0.05，高斯随机场校正），CTN患者双侧初级感觉运动皮层，右侧辅助运动区、颞下皮层和小脑，左侧丘脑、边缘叶/海马旁回和颞上/中皮层ReHo值增高；双侧前额皮层/眶额皮层和脑岛，右侧额内侧皮层和颞上皮层，左侧前扣带回、缘上回和小脑ReHo值减低。右额内侧皮层ReHo值与病程呈负相关（r=-0.45，P=0.03）；左侧初级感觉运动皮层ReHo值与VAS评分（r=0.46，P=0.02）呈正相关。结论 CTN患者存在疼痛相关功能脑区自发功能活动一致性的异常，有助于对CTN发生机制的理解。 |
| 英文摘要: |
| Objective To investigate the alterations of regional spontaneous activity in patients with classical trigeminal neuralgia (CTN) during resting state. Methods Twenty-seven patients with CTN (CTN group) and 27 healthy subjects (control group) were recruited and underwent a rest-state functional MRI. The regional homogeneity (ReHo) analysis was used to compare the differences of regional synchronization of spontaneous brain activity. And correlation tests were performed between ReHo values in the abnormal brain areas and clinical metrics (visual analogue scale and disease duration) of the disease. Results Compared with control group (P<0.05, Gaussian random field correction), ReHo increased in bilateral primary somatosensory cortex (S1) and primary motor cortex (M1), right supplementary motor area (SMA), inferotemporal cortex and cerebellum, left thalamus, limbic lobe, parahippocampa gyrus, middle and superior temporal gyrus in CTN group; ReHo decreased in bilateral insula, prefrontal cortex and orbitofrontal cortex, right frontal medial cortex and superior temporal gyrus, left anterior cingulate area, supramarginal gyrus and cerebellum in CTN group. ReHo values in right frontal medial cortex was negatively correlated with the course of disease (r=-0.45, P=0.03). The ReHo values of left primary sensorimotor cortex were positively correlated with the visual analogue scale scores (r=0.46, P=0.02). Conclusion CTN patients has abnormal functional homogeneity of spontaneous brain activity in regions involved in the pain processing, which can help understanding mechanism of CTN. |
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