| 兰莲君,舒健,陆笑非,陈文,李芹.肝脏T2值评估HBV相关慢加急性肝衰竭[J].中国医学影像技术,2017,33(6):902~906 |
| 肝脏T2值评估HBV相关慢加急性肝衰竭 |
| Hepatic T2 value in evaluation of HBV based acute-on-chronic liver failure |
| 投稿时间：2016-10-07 修订日期：2017-03-15 |
| DOI：10.13929/j.1003-3289.201610013 |
| 中文关键词: 肝功能衰竭 磁共振成像 T2值 |
| 英文关键词:Liver failure Magnetic resonance imaging T2 value |
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| 中文摘要: |
| 目的 探讨肝脏T2值对HBV相关慢加急性肝衰竭的评估价值。方法 收集HBV相关慢加急性肝衰竭（HBV-ACLF）组、慢性乙型肝炎组和正常对照组，分别对3组受检者行多回波梯度-自旋回波（M-GRASE）序列扫描，获得T2图，并计算肝脏平均T2值及T2弛豫率（R2）。收集HBV-ACLF组和慢性乙型肝炎组MR检查前2天内肝功能血液生化指标。比较3组间T2和R2值的差异及T2值与生化指标的相关性，采用ROC曲线评价T2值对HBV-ACLF的诊断效能。结果 3组间T2值（χ2=19.074，P<0.001）和R2值（F=10.411，P<0.001）差异均有统计学意义。T2值诊断慢加急性肝衰竭曲线下面积为0.86（P<0.001），诊断阈值为57.73 ms（R2=0.017）。T2值与凝血酶原时间国际标准化比值（INR）、凝血酶原时间（PT）及透明质酸（HA）呈中度正相关（rs=0.65、0.67、0.39，P均<0.05），与凝血酶原活动度（PTA）、白蛋白（ALB）、前白蛋白（PA）呈中度负相关（rs=-0.67、-0.48、-0.37，P均<0.05）。结论 T2或R2值可较好地反映肝脏功能情况，并与较多的肝功能实验室指标均具有相关性，对HBV-ACLF具有较好的诊断效能。 |
| 英文摘要: |
| Objective To investigate the value of hepatic T2 value in evaluation of chronic HBV-related acute-on-chronic liver failure (HBV-ACLF). Methods The HBV-ACLF group, chronic hepatitis B group and control group who underwent liver MRI (M-GRASE sequence) were enrolled. The T2 map was produced from the post-processing software, and the mean T2 and R2 value of liver was calculated. The blood biochemical indexes from HBV-ACLF and chronic hepatitis B group were collected in 2 days pre-MR scaning. The differences of T2 and R2 values among 3 groups and the correlation between biochemical indexes and T2 value were analyzed. ROC curve was conducted to evaluate diagnostic efficiency of T2 value for HBV-ACLF. Results There were significant differences of T2 value (χ2=19.074, P<0.001) or R2 value (F=10.411, P<0.001) among the 3 groups. The AUC of T2 value for diagnosing HBV-ACLF was 0.86 (P<0.001), with the cut-off value 57.73 ms (R2=0.017). Moderate positive correlation was shown between T2 values and international normalized ratio (INR), prothrombin time (PT), haluronicacid (HA) values (rs=0.65, 0.67, 0.39, all P<0.05), and moderate negative correlation was shown between T2 values and prothrombin activity (PTA), albumin (ALB), prealbumin (PA) values (rs=-0.67, -0.48, -0.37, all P<0.05). Conclusion T2 or R2 value could reflect the liver function, and were correlated with some biochemical indexes, which illustrated a good diagnostic efficiency for diagnostic of HBV-ACLF. |
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