| 戴甜甜,魏清阳.质子和重离子治疗在线监测成像技术的研究进展[J].中国医学影像技术,2017,33(2):312~315 |
| 质子和重离子治疗在线监测成像技术的研究进展 |
| Research progresses of on-line imaging technologies for proton and heavy ion therapy monitoring |
| 投稿时间：2016-07-14 修订日期：2016-12-06 |
| DOI：10.13929/j.1003-3289.201607064 |
| 中文关键词: 质子/重离子治疗 在线成像监测 正电子发射断层成像 准直单光子成像 康普顿散射成像 |
| 英文关键词:Proton/heavy ion therapy On-line imaging monitoring Positron-emission tomography Collimated single photon imaging Compton imaging |
| 基金项目:国家自然科学基金（11505300）；中央高校基本科研业务费专项资金（FRF-TP-15-114A1）。 |
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| 中文摘要: |
| 不同于传统的高能电子线和光子线治疗，质子/重离子治疗利用重带电粒子与物质作用的布拉格曲线特性，将主要能量沉积在癌变组织上，从而最大限度地保护正常组织和器官。由于质子/重离子在治疗过程中的射程和剂量存在不确定性，因而对其射程和剂量的监测和验证尤为重要。治疗过程中质子/重离子与组织相互作用能够释放出正电子和瞬发γ光子。对这些粒子进行探测成像可实时反映质子/重离子的能量沉积情况。目前在线监测成像技术尚处在研究和初步临床试验阶段，其中主要的3种技术包括：in-beam PET、准直单光子成像和康普顿散射成像。本文介绍这3种技术的原理、优缺点和研究进展，并对质子/重离子治疗在线监测成像技术的发展方向进行展望。 |
| 英文摘要: |
| Compared with conventional electron and photon radiotherapy, proton and heavy ion therapy utilizing the Bragg curve characteristic of heavy charged particles, can deposit the main energy to the tumor, while maximally protecting the surrounding normal tissues and critical organs. Because of the range and dose uncertainties in the course of proton/heavy ion therapy treatment, monitoring and verification of the range and dose is particularly important. During dose delivery, heavy charged particle interaction with tissue could emit positrons and prompt gammas. Therefore, real-time detection and imaging of these particles could show the distribution of energy deposition. So far, online monitoring imaging technologies have still been in research and initial clinical study stage, and the main three technologies include in-beam PET, collimated single photon imaging and Compton imaging. The principle, advantages, disadvantages and research progresses of these three technologies, and the future direction of on-line imaging technology for proton/heavy ion therapy monitoring were reviewed in this article. |
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