| 马新欣,张跃力,王曼,郑东燕,薛晓培,朱梦若,江文君.自发性高血压大鼠左心室心肌应变与心肌纤维化程度的相关性[J].中国医学影像技术,2017,33(2):161~166 |
| 自发性高血压大鼠左心室心肌应变与心肌纤维化程度的相关性 |
| Relationship between left ventricular global strain and myocardial fibrosis in spontaneously hypertension rats |
| 投稿时间：2016-07-08 修订日期：2016-12-06 |
| DOI：10.13929/j.1003-3289.201607040 |
| 中文关键词: 超声心动描记术 高血压 斑点追踪应变显像 应变 心肌纤维化 |
| 英文关键词:Echocardiography Hypertension Speckle tracing echocardiography Strain Myocardial fibrosis |
| 基金项目:上海市科学技术委员会科研计划项目（134119a5801）。 |
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| 中文摘要: |
| 目的 探讨自发性高血压大鼠（SHR）左心室心肌应变与心肌纤维化程度的关系。方法 选取10周龄雄性SHR及Wistar-Kyoto大鼠（WKY）各15只，均随机平均分为3个亚组。12周后每2周行常规超声及二维斑点追踪显像（2DSTE），于左心室长轴和乳头肌水平短轴切面测量左心室整体纵向应变（GLS）、径向应变（GRS）及周向应变（GCS）峰值。分别于16、20、24周将SHR和WKY各取1个亚组处死，行心脏离体固定、Masson染色，观察心内膜下和心外膜下层心肌胶原容积分数（CVF）、血管周围胶原面积与管腔面积比率（PVCA/LA）。结果 与同周龄WKY相比，SHR的GLS自16周、GRS自18周、GCS自20周显著降低，差异均有统计学意义（P均<0.05）。SHR的GLS与心内膜下CVF呈正相关（r=0.65，P<0.05）；GLS、GCS与PVCA/LA呈正相关（r=0.65、0.63，P均<0.05），GRS与PVCA/LA呈负相关（r=-0.59，P<0.05）。结论 2DSTE技术可无创评价大鼠心肌形变，其与心肌纤维化程度具有良好的相关性。 |
| 英文摘要: |
| Objective To investigate the relationship between left ventricular strain and myocardial fibrosis in spontaneously hypertension rats (SHR).Methods Totally 15 SHR and 15 Wistar-Kyoto rats(WKY) with 10 weeks old were observed, each group was randomly divided into 3 subgroups. Echocardiography and two-dimensional speckle tracing echocardiography (2DSTE) were performed every two week from 12 weeks. two-dimensional dynamics images were required from the left ventricular long axis view and papillary muscle short axis view, and then the left ventricular peak global longitudinal strain (GLS), radial strain (GRS) and circumferential strain (GCS) were measured. One subgroup of SHR and WKY rats were killed and hearts were isolated at 16, 20 and 24 weeks respectively. The myocardium were fixed and performed Masson staining to observe collagen volume fraction (CVF) in subendocardial and subepicardial myocardium, perivascular collagen area to luminal area ratio (PVCA/LA).Results Compared with WKY rats, global strain of SHR significantly decreased, GLS significantly decreased since 16 weeks, GRS decreased since 18 weeks and GCS decreased since 20 weeks (all P<0.05). GLS was positively correlated with subendocardial CVF (r=0.65, P<0.05). GLS and GCS were positively correlated with PVCA/LA (r=0.65, 0.63, both P<0.05), and GRS was negatively correlated with PVCA/LA (r=-0.59, P<0.05).Conclusion 2DSTE can be used to analyze the myocardial strain non-invasively and it has a good correlation with the degree of myocardial fibrosis. |
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