| 尹安雨,张娜,何品,夏军.MRI定量分析颈动脉粥样硬化斑块脂质坏死核:与手术病理对照[J].中国医学影像技术,2017,33(1):21~24 |
| MRI定量分析颈动脉粥样硬化斑块脂质坏死核:与手术病理对照 |
| MRI quantitative analysis of lipid-rich necrotic core of carotid atherosclerotic plaque: Compared with histopathology |
| 投稿时间：2016-06-21 修订日期：2016-10-16 |
| DOI：10.13929/j.1003-3289.201606101 |
| 中文关键词: 颈动脉 斑块,粥样硬化 磁共振成像 病理学 |
| 英文关键词:Carotid arteries Plaque,atherosclerotic Magnetic resonance imaging Pathology |
| 基金项目:深圳市科技计划基础研究项目（JCYJ20130329111053590）、深圳市科技计划技术攻关项目（JSGG20141020103440414）。 |
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| 中文摘要: |
| 目的 探讨MRI定量分析颈动脉斑块内脂质坏死核心（LRNC）的准确性。方法 对19例颈动脉内膜剥脱术（CEA）患者术前行MR颈动脉检查，于MRI图像和病理组织学切片上分别测量LRNC的大小，计算其所占总管壁面积的百分比，分析两者的相关性。结果 共151个MRI图像层面与患者的病理组织学区域相匹配，MRI与组织学测得LRNC占总管壁面积的百分比分别为（20.64±9.03）%和（18.65±9.49）%，两者具有中-高度相关性（r=0.69，P<0.001）。结论 MRI可定量测量颈动脉斑块内LRNC，有助于预测斑块的稳定性。 |
| 英文摘要: |
| Objective To explore the accuracy of MRI in the quantitative evaluation of lipid-rich necrotic core (LRNC) of carotid atherosclerotic plaque in vivo. Methods Nineteen patients were underwent carotid MRI before carotid endarterectomy (CEA). MR images and histology specimens were reviewed for quantitative measurements of LRNC areas. Percentages of LRNC areas to the total vessel area were recorded to analyze the correlation between MR images and histology specimens. Results There were 151 MR images matched histology specimens. The mean percentages of LRNC areas measured by MRI and histology were (20.64±9.03)% and (18.65±9.49)%, which had moderate to strong correlation (r=0.69, P<0.001). Conclusion MRI can quantitatively measure the LRNC of carotid atherosclerotic plaque, which may be useful in predicting the risk of plaque. |
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