| 李正然,常天静,王子璇,张玮艺,詹亚峰,刘勇,王春雪,沈慧聪.老年人脑白质病变相关性跌倒的脑静息态功能磁共振成像[J].中国医学影像技术,2016,32(11):1659~1663 |
| 老年人脑白质病变相关性跌倒的脑静息态功能磁共振成像 |
| Resting state fMRI on white matter lesions in the aged with fall risk |
| 投稿时间：2016-04-13 修订日期：2016-08-16 |
| DOI：10.13929/j.1003-3289.2016.11.009 |
| 中文关键词: 白质 意外跌倒 静息态功能磁共振成像 |
| 英文关键词:White matter Accidental falls Resting state functional magnetic resonance imaging |
| 基金项目:首都临床特色应用研究与成果推广(Z151100004015127)。 |
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| 中文摘要: |
| 目的 探讨老年人脑白质病变（WMLs）相关性跌倒患者的脑静息态fMRI（rs-fMRI）特征。方法 前瞻性选取本院60岁以上的WMLs患者40例，均接受rs-fMRI检查，根据Tinetti平衡和步态量表划分为跌倒风险组（Tinetti<25，n=11）及对照组（Tinetti≥25，n=29）。应用SPM 8软件进行图像处理，识别跌倒风险患者脑网络内及网络间的功能连接异常，并与简易精神状态检查量表（MMSE）、蒙特利尔认知评估量表（MoCA）评分进行相关性分析。结果 跌倒风险组的MMSE（t=4.04，P<0.01）及MoCA（t=3.88，P<0.01）量表评分低于对照组。与对照组比较，跌倒风险组的记忆网络（MeN）脑功能连接减弱（t=2.87，P=0.01）；带状盖任务控制网络（CON）和腹侧注意网络（VAN）的功能连接减弱（t=2.59，P =0.01）；默认网络（DMN）和额顶任务控制网络（FPN）的功能连接增强（t=-2.13，P=0.04），所有WMLs患者的MeN网络内功能连接与MoCA评分（r=0.39，P=0.01）呈正相关；DMN和FPN功能连接与MMSE（r=-0.40，P=0.01）及MoCA（r=-0.37，P=0.02）呈负相关。结论 具有跌倒风险的WMLs患者存在脑网络内及网络间的功能连接异常，并与其认知功能改变存在一定的相关性。 |
| 英文摘要: |
| Objective To analyze the resting state fMRI (rs-fMRI) characteristics in the aged who had white matter lesions (WMLs) with fall risks. Methods A total of 40 patients (age>60 years) with WMLs were enrolled in this prospective study.And all the patients were performed rs-fMRI. According to the Tinetti Balance and Gait Analysis, all patients were divided into experimental group (Tinetti<25, n=11) and contrast group (Tinetti≥25, n=29). SPM 8 software was used to analyze the data of rs-fMRI, and the abnormal functional connectivity was identified and made correlation analysis with montreal cognitive assessment (MoCA) and mini-mental state examination (MMSE) scores. Results There were statistical differences in the scores of MMSE (t=4.04, P<0.01) and MoCA (t=3.88, P<0.01) between two groups. Compared with control group, the intra-functional connectivity of memory retrieval (MeN) decreased in experimental group (t=2.87, P=0.01). The functional connectivity between cingulo-opercular control network (CON) and ventral attention network (VAN) decreased (t=2.59, P=0.01) and the functional connectivity between default mode network (DMN) and fronto-parietal task control network (FPN) increased (t=-2.13, P=0.04) in experimental group. The intra-functional connectivity of MeN in all the patients showed positive correlation with MoCA scores (r=0.39, P=0.01). And the functional connectivity of DMN and FPN showed negative correlation with MMSE scores (r=-0.40, P=0.01) and MoCA scores (r=-0.37, P=0.02). Conclusion In WMLs patients with fall risks, some intra-network and inter-network functional connectivities show significant differences, and these differences are correlated with cognitive performance scores. |
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