| 郭油油,李咏梅,刘义,张小辉,时晓清,廖旦.多发性硬化患者中枢听觉传导通路的扩散张量成像[J].中国医学影像技术,2016,32(11):1654~1658 |
| 多发性硬化患者中枢听觉传导通路的扩散张量成像 |
| Diffusion tensor imaging of central auditory pathway lesion in multiple sclerosis patients |
| 投稿时间：2015-12-30 修订日期：2016-07-25 |
| DOI：10.13929/j.1003-3289.2016.11.007 |
| 中文关键词: 多发性硬化 听神经 纤维示踪成像 磁共振成像 |
| 英文关键词:Multiple sclerosis Auditory nerve Tractography Magnetic resonance imaging |
| 基金项目:国家自然科学基金（81371523）、国家临床重点专科建设项目（[2013]544）、重庆市卫生局资助项目（2011-1-031、2012-1-017）。 |
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| 中文摘要: |
| 目的 采用扩散张量成像（DTI）和纤维追踪技术探讨有听力损害的多发性硬化（MS）患者听觉中枢传导通路的纤维显微结构改变。方法 收集存在听力损害的MS患者15例（MS组），其中单侧听力损害8例，双侧7例；另收集健康对照组15名。以MS组和对照组脑干内外侧丘系（LL）、中脑下丘（IC）分别为ROI1、ROI2进行DTI；再借助纤维追踪技术观察两侧颞横回（ROI3）中枢听觉皮层的纤维走行，比较两组不同ROI神经纤维的FA、ADC值，并分析MS组单侧听力损害患者有差异的DTI参数值与临床扩展致残量表（EDSS）评分和病程的相关性。结果 MS组双侧听力损害患者的听觉传导通路ROI1（P=0.016）、ROI2（P=0.038）、ROI3（P=0.007）的FA均低于对照组，ROI1（P=0.016）、ROI2（P=0.039）ADC值高于对照组，ROI3的ADC值与对照组差异无统计学意义（P=0.108）。MS组单侧听力损伤患者的损伤侧仅ROI1（P=0.022）、ROI3（P=0.029）FA低于对照组。MS组单侧听力损害患者有差异的DTI参数值与EDSS评分、病程均无相关性。结论 MS患者中枢听觉传导通路DTI参数存在异常，可为临床听力损害提供直接证据。 |
| 英文摘要: |
| Objective To explore fiber microstructure changes of the auditory pathway of multiple sclerosis (MS) patients with hearing impairment based on diffusion tensor imaging (DTI) and deterministic fiber tracking technology. Methods Fifteen MS patients (MS group) with hearing impairment, including 8 cases with unilateral hearing damages and 7 cases with bilateral hearing damages were enrolled; 15 healthy controls were collected at the same time (control group). DTI was performed, lateral lemniscus was ROI1 and inferior colliculus was ROI2; fiber tracking technology was used to observe transverse temporal gyri (ROI3) fibers of the central auditory cortex of both groups. FA and ADC values of ROI in two groups were compared. The relationships of DTI parameter which had statistical difference in unilateral hearing damages patients with expanded disability states scale (EDSS) scores, course of disease were analyzed. Results Compared with control group, FA of ROI1(P=0.016), ROI2(P=0.038), ROI3 (P=0.007) were lower, ADC values of ROI1 (P=0.016), ROI2 (P=0.039) were higher in MS patients with bilateral hearing impairment. There were no statistically significance of ADC of ROI3 between MS patients with bilateral hearing impairment and control group (P=0.108). Compared with control group, FA of ROI1 (P=0.022) and ROI3 (P=0.029) were lower in MS patients with unilateral hearing damages. FA of ROI1 and ROI3 in MS patients with unilateral hearing impairment had no correlation with EDSS scores and course of disease. Conclusion Central auditory pathway in MS patients with abnormal DTI parameters can provide direct evidence for clinical hearing impairment. |
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