| 唐翠,续晋铭,卢晓玲,邱诗雄,张兰花,滕美珠,左晓明,王培军.不同病理特征直肠癌的MR灌注成像参数分析[J].中国医学影像技术,2016,32(10):1540~1544 |
| 不同病理特征直肠癌的MR灌注成像参数分析 |
| MR perfusion imaging parameters analysis of rectal cancers with different pathologic characteristics |
| 投稿时间：2016-04-26 修订日期：2016-07-20 |
| DOI：10.13929/j.1003-3289.2016.10.017 |
| 中文关键词: 直肠肿瘤 磁共振成像 病理学 |
| 英文关键词:Rectal neoplasms Magnetic resonance imaging Pathology |
| 基金项目:2015年度上海市杨浦区卫计委、科委青年项目（YP15Q07） |
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| 中文摘要: |
| 目的 探讨不同病理特征直肠癌MR灌注成像参数的改变。方法 回顾性分析经病理确诊为直肠癌的35例患者影像及病理资料，所有患者均接受MR灌注成像检查，并获得直肠癌和癌周正常直肠壁各MR灌注参数值[对比剂容积转换常数（Ktrans）、速率常数（Kep）、血管外细胞外间隙容积分数（Ve）及初始强化曲线下面积（iAUC）]。分析病理学特征，包括组织分化程度、T分期、N分期、脉管浸润和神经周围浸润情况；对不同病理状态的MR灌注参数值进行统计学分析。结果 直肠癌Ktrans及iAUC均高于癌周正常直肠壁（P均<0.05），直肠癌Ve低于癌周正常直肠壁（P<0.05），Kep差异无统计学意义（P=0.345）。不同组织分化程度直肠癌的Ktrans、Ve、Kep和iAUC差异均无统计学意义（P均>0.05）。T3~4期直肠癌Ktrans及Kep较T1~2期显著升高（P均<0.05）；T1~2期与T3~4期直肠癌的iAUC及Ve差异无统计学意义（P均>0.05）。N1~2分期的Kep高于N0分期（P=0.006），余各灌注参数差异均无统计学意义（P均>0.05）。有无脉管浸润和神经周围浸润的直肠癌MR灌注参数差异均无统计学意义（P均>0.05）。结论 直肠癌的MR灌注成像参数可反映其不同病理特征。 |
| 英文摘要: |
| Objective To explore MR perfusion imaging parameters changes of rectal cancers with different pathologic characteristics.Methods Image and pathological data of 35 patients with rectal cancer confirmed by pathology were retrospectively analyzed. MR perfusion imaging scan were performed on all patients. The perfusion parameters of rectal cancer and normal rectal beside rectal cancer were calculated, including contrast agent volume transfer constant (Ktrans), rate constant (Kep), extravascular extracellular space fractional volume (Ve) and initial area under curve (iAUC). Pathological characteristics of rectal cancer were analyzed, including tumor differentiation degree, T stage, N stage, vascular invasion and perineural invasion. Statistical analysis of perfusion parameters in different pathologic states was carried out.Results Compared with normal rectum, rectal cancer had higher Ktrans and iAUC (both P<0.05), lower Ve (P<0.05), but Kep had no significant difference (P=0.345). Ktrans, Ve, Kep and iAUC of different pathology differentiation degree rectal cancer all had no statistical significance (all P>0.05). Compared with T1-2 stage, T3-4 stage of rectal cancer had higher Ktrans and Kep (both P<0.05), but iAUC and Ve had no significant difference (both P>0.05). Compared with N0 stage, N1-2 stage of rectal cancer had higher Kep (P=0.006), and other perfusion parameters all had no significant difference (all P>0.05). MR perfusion parameters of rectal cancer with vascular and perineural invasion or not had no significant difference (both P>0.05).Conclusion MRI perfusion parameters can reflect different pathological characteristics of rectal cancer. |
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