| 单艳棋,相丽,邹立巍,徐佳佳,郑穗生.中青年终末期肾脏病腹膜透析患者脑白质损伤与认知功能改变的相关性研究[J].中国医学影像技术,2016,32(10):1485~1489 |
| 中青年终末期肾脏病腹膜透析患者脑白质损伤与认知功能改变的相关性研究 |
| Correlation between white matter alterations and cognitive function damage in young and middle-aged end-stage renal disease patients with peritoneal dialysis |
| 投稿时间：2016-05-24 修订日期：2016-07-19 |
| DOI：10.13929/j.1003-3289.2016.10.003 |
| 中文关键词: 肾脏病 认知功能 扩散磁共振成像 基于纤维束追踪空间统计分析 |
| 英文关键词:Kidney diseases Cognitive function Diffusion magnetic resonance imaging Tract-based spatial statistics |
| 基金项目:安徽省质量工程项目（2014jxtd119）、安徽省公益性研究联动计划项目（1604f0804025） |
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| 中文摘要: |
| 目的 探讨中青年终末期肾病（ESRD）腹膜透析患者脑白质（WM）损伤与认知功能改变的相关性。方法 选取被确诊为ESRD并接受腹膜透析治疗的患者21例（ESRD组），同期选取20名健康志愿者（对照组）。行MR平扫和DTI扫描，获得DTI参数，包括各项异性系数（FA）、平均扩散系数（MD）、平行扩散系数（AD）、径向扩散系数（RD）。采用基于纤维束示踪的空间统计方法获得DTI参数有差异的脑区。两组受检者均接受简易智能精神状态检查量表（MMSE）评分。对差异脑区的FA、MD、AD及RD值与MMSE评分进行相关性分析。结果 两组受检者常规MR平扫WM均无明显异常。与对照组比较，ESRD组MMSE评分较低（P<0.05），多个脑区的FA值降低，MD、RD及AD值升高（P均<0.05，体素均>100个）。差异脑区的FA、MD、AD及RD值与MMSE评分无相关性（P均>0.05）。结论 常规MR平扫WM无明显异常的中青年ESRD腹膜透析患者WM纤维束完整性降低、脱髓鞘改变，并伴轻度认知功能减退。 |
| 英文摘要: |
| Objective To investigate the correlation between white matter (WM) alterations and cognitive function damage in young and middle-aged end-stage renal disease (ESRD) patients with peritoneal dialysis.Methods Totally 21 ESRD patients accepted peritoneal dialysis (ESRD group) were collected, and 20 healthy volunteers were also collected. MR plain scan and DTI scan were performed, and DTI parameters were obtained, including fractional anisotropy (FA), mean diffusivity (MD), axial diffusivity (AD) and radial diffusivity (RD). Tract-based spatial statistics analyses were performed to obtain WM area, which DTI parameters had significant difference in 2 groups. Mini mental state examination (MMSE) scores and statistical analysis were carried out.Results There was no obvious abnormal in MR plain scan images in 2 groups. Compared to control group, MMSE scores was lower in ESRD group (P<0.05); FA value of several WM areas decreased, MD, RD and AD value of several WM areas increased in ESRD group (all P<0.05, all voxel number>100). There was no correlation between FA, MD, AD and RD value of WM areas with difference and MMSE scores (all P<0.05).Conclusion WM fiber bundle integrity has reduced and demyelinated, and cognitive function has declined mildly in young and middle-aged ESRD patients with peritoneal dialysis, although there is no obvious abnormal in MR plain scan images. |
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