| 庄仲,刘舰,李飞宇,彭晓刚,赵锡海.轻度狭窄与无狭窄颈动脉斑块高分辨率MRI特征[J].中国医学影像技术,2016,32(8):1209~1213 |
| 轻度狭窄与无狭窄颈动脉斑块高分辨率MRI特征 |
| High resolution MRI features of atherosclerotic plaque in carotid arteries with low-grade and non-stenosis |
| 投稿时间：2015-10-19 修订日期：2016-01-08 |
| DOI：10.13929/j.1003-3289.2016.08.015 |
| 中文关键词: 颈动脉狭窄 斑块,动脉粥样硬化 磁共振成像 |
| 英文关键词:Carotid stenosis Plaque, atherosclerotic Magnetic resonance imaging |
| 基金项目:国家自然科学基金面上项目（81271536）。 |
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| 中文摘要: |
| 目的 探讨脑血管病患者轻度狭窄或无狭窄颈动脉粥样硬化（AS）斑块的高分辨率MRI（HRMRI）特征。方法 对103例近期出现脑血管病症状且伴颈动脉AS斑块的患者行颈动脉HRMRI。排除图像质量差或颈动脉严重狭窄（狭窄程度≥50%）者。对颈动脉斑块进行定性和定量分析，比较无狭窄（无狭窄组）与轻度狭窄（轻度狭窄组，狭窄程度1%～49%）颈动脉AS斑块的负荷及成分特征差异。结果 最终86例患者共155支颈动脉血管纳入研究，轻度狭窄组24支，无狭窄组131支。无狭窄与轻度狭窄组颈动脉管腔面积[（53.40±15.29）mm2 vs （41.30±11.57）mm2， P<0.001]和最大管壁厚度[（2.16±0.90）mm vs （3.30±1.25）mm， P=0.014]差异均有统计学意义，而管壁面积[（31.69±6.80）mm2 vs （32.80±9.33）mm2， P=0.581]差异无统计学意义。无狭窄组和轻度狭窄组存在中度风险斑块、高风险斑块者分别占10.69%（14/131）、6.11%（8/131）和20.83%（5/24）、20.83%（5/24）。颈动脉最大管壁厚度与管腔狭窄程度之间呈正相关（r=0.430，P<0.001）。结论 无狭窄或轻度狭窄的颈动脉血管仍存在发生不稳定斑块的风险。 |
| 英文摘要: |
| Objective To evaluate the characteristics of high resolution MRI (HRMRI) in atherosclerotic plaques of low-grade and non-stenosis carotid arteries. Methods A total of 103 patients with recent cerebrovascular symptoms and carotid plaques were underwent carotid HRMRI. Arteries with poor image quality or severe luminal stenosis (≥50%) were excluded. MR images were reviewed for qualitative and quantitative evaluation of plaque characteristics. The plaque burden and the compositional features between carotid arteries with low-grade stenosis (1%-49%) and without stenosis were compared. Results Totally 86 patients (155 carotid arteries) were recruited in this study. Of all patients, 155 carotid arteries including 24 with low-grade stenosis and 131 without stenosis were qualified for analysis. Statistically significant differences were found in lumen area ([53.40±15.29] mm2 vs [41.30±11.57]mm2, P<0.001) and maximum wall thickness ([2.16±0.90] mm vs [3.30±1.25]mm, P=0.014) between carotid arteries with low-grade stenosis and without stenosis. But no significant differences was found in wall area ([31.69±6.80]mm2 vs [32.80±9.33]mm2, P=0.581). The prevalence of middle and high risk plaques were 10.69% (14/131) and 6.11% (8/131) in carotid arteries without stenosis, 20.83% (5/24) and 20.83% (5/24) in carotid arteries with low-grade stenosis. The maximum wall thickness of carotid artery correlated positively with the degree of stenosis (r=0.430, P<0.001). Conclusion Carotid arteries with low-grade stenosis and without stenosis are still at the risk to develop vulnerable plaque. |
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