| 洪永强,刘欢,吴秀琴,张晓滨,黄孟华,王靖,王宏宇.中国福建畲族自然人群血管结构功能及其影响因素[J].中国医学影像技术,2016,32(8):1200~1204 |
| 中国福建畲族自然人群血管结构功能及其影响因素 |
| Vascular function and structure and related influencing factors in Fujian She nationality Chinese |
| 投稿时间：2015-11-25 修订日期：2016-06-16 |
| DOI：10.13929/j.1003-3289.2016.08.013 |
| 中文关键词: 畲族 脉搏波传导速度 动脉僵硬度 颈动脉 内-中膜厚度 超声检查 |
| 英文关键词:She nationality Pulse wave velocity Arterial stiffness Carotid arteries Iintima-media thickness Ultrasonography |
| 基金项目:卫生部十年百项计划项目（04-10-01）、2014年福建省医学创新课题（2014-CXB-25）。 |
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| 中文摘要: |
| 目的 探讨中国福建畲族自然人群血管结构功能及其影响因素。方法 选取358名福建畲族志愿者，根据颈-股动脉脉搏波传导速度（cf-PWV）不同分为动脉弹性正常组（cf-PWV≤9 m/s，144名）和动脉弹性降低组（cf-PWV>9 m/s，214名）。应用多普勒超声诊断仪测定左侧颈动脉内膜-中层厚度（L-CIMT）、右侧颈动脉内膜-中层厚度（R-CIMT），并进行实验室检查测定总胆固醇（TC）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）、甘油三酯（TG）、空腹血糖（FPG）、尿酸（UA）、尿素氮（BUN）、肌酐（Cr）、超敏C反应蛋白。并进行统计学分析。结果 动脉弹性降低组的L-CIMT、R-CIMT、年龄、心率、收缩压、舒张压、脉压、BUN、Cr、FPG、TG、TC、cf-PWV、LDL-C水平均显著高于动脉弹性正常组（P均<0.05）。动脉硬化的危险因素包括年龄、心率、收缩压、BUN、TC，而LDL-C是动脉硬化的保护因素。动脉弹性降低组和动脉弹性正常组cf-PWV与L-CIMT、R-CIMT均呈正相关（r=0.369、0.316，0.223、0.171，P均<0.05）。L-CIMT的独立影响因素为年龄和收缩压（P均<0.05），R-CIMT的独立影响因素为年龄和脉压（P均<0.05）。结论 中国福建畲族自然人群的年龄、心率、收缩压、BUN、TC是动脉硬化的危险因素，cf-PWV与双侧CIMT均呈正相关。 |
| 英文摘要: |
| Objective To investigate vascular function and structure and related influencing factors in Fujian She nationality Chinese. Methods A total of 358 Fujian She nationality volunteers were collected. According to the carotid femoral pulse wave velocity (cf-PWV) values, the volunteers were divided into two groups: Normal arterial elasticity group (cf-PWV≤9 m/s, n=144) and arterial elasticity decreased group (cf-PWV>9 m/s, n=214). They all underwent detection of left carotid intima media thickness (L-CIMT), right carotid intima media thickness (R-CIMT), and laboratory examination such as total cholesterol (TC), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), triglyceride (TG), fasting plasma glucose (FPG), uric acid (UA), urea nitrogen (BUN), creatinine (Cr) and high sensitive C reactive protein. The indexes were statistically analyzed. Results L-CIMT, R-CIMT, age, heart rate, systolic blood pressure, diastolic blood pressure, pulse pressure, BUN, Cr, FPG, TG, TC, cf-PWV, LDL-C were significantly higher in arterial elasticity decreased group than those in normal arterial elasticity group (all P<0.05). Age, heart rate, systolic blood pressure, BUN and TC were risk factors of arterial stiffness, and LDL-C was protecting factor. The cf-PWV was positively correlated with both of L-CIMT and R-CIMT in arterial elasticity decreased group and normal arterial elasticity group (r=0.369, 0.316 and r=0.223, 0.171, all P<0.05). Age and systolic blood pressure were independent influencing factors of L-CIMT (both P<0.05), and age and pulse pressure were independent influencing factors of R-CIMT (both P<0.05). Conclusion Age, heart rate, systolic blood pressure, BUN, and TC are risk factors of arterial stiffness in Fujian She nationality Chinese. In addition, cf-PWV were both positively correlated with L-CIMT and R-CIMT. |
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