| 姜东朗,冯洪波,邱湘哲,张延军.18F-FDG PET/CT评价糖尿病前期患者脑葡萄糖代谢的改变[J].中国医学影像技术,2016,32(8):1184~1188 |
| 18F-FDG PET/CT评价糖尿病前期患者脑葡萄糖代谢的改变 |
| 18F-FDG PET/CT in evaluation of glucose metabolism change in prediabetes patients' brain |
| 投稿时间：2015-12-22 修订日期：2016-06-20 |
| DOI：10.13929/j.1003-3289.2016.08.009 |
| 中文关键词: 糖尿病前期 脑 葡萄糖代谢 氟脱氧葡萄糖F18 体层摄影术,发射型计算机 |
| 英文关键词:Prediabetic state Brain Glucose metabolism Fludeoxyglucose F 18 Tomography, emission-computed |
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| 中文摘要: |
| 目的 探讨18F-FDG PET/CT评价糖尿病前期脑葡萄糖代谢改变的特点。方法 收集接受全身18F-FDG PET/CT检查的患者105例，按空腹血糖水平分为3组：糖尿病前期组（5.6 mmol/L≤空腹血糖≤6.9 mmol/L），高血糖水平正常组（5.1 mmol/L≤空腹血糖<5.6 mmol/L）及低血糖水平正常组（4.6 mmol/L≤空腹血糖<5.1 mmol/L），每组各35例。采用SPM 12软件对3组图像进行基于体素的统计学分析比较。结果 高血糖水平正常组与低血糖水平正常组比较，未出现葡萄糖代谢减低脑区。糖尿病前期组与高血糖水平正常组比较，出现葡萄糖代谢减低脑区，包括左侧额中回（BA47）、左侧额下回（BA45）、右侧额中回（BA10）、右侧额下回（BA45、BA47）。糖尿病前期组与低血糖水平正常组比较，出现葡萄糖代谢减低脑区，包括左侧额中回（BA47）、左侧额下回（BA47、BA45、BA9）、右侧额中回（BA10）。结论 糖尿病前期患者的部分脑区出现葡萄糖代谢减低，提示糖尿病的前期阶段已经出现脑功能异常。 |
| 英文摘要: |
| Objective To investigate the features of 18F-FDG PET/CT in evaluation of glucose metabolism change in prediabetes patients' brain. Methods Totally 105 patients underwent whole body 18F-FDG PET/CT scan were divided into 3 groups based on fasting plasma glucose levels: Prediabetes group (5.6 mmol/L≤fasting plasma glucose levels≤6.9 mmol/L), high blood glucose level group (5.1 mmol/L≤fasting plasma glucose levels<5.6 mmol/L) and low blood glucose level group (4.6 mmol/L≤fasting plasma glucose levels<5.1 mmol/L). There were 35 cases in each group. The differences of three groups were analyzed and compared statistically by SPM 12 based on voxel. Results Compared to low blood glucose level group, there was no glucose metabolism decreased encephalic region in high blood glucose level group. Compared to high blood glucose level group, prediabetes group had glucose metabolism decreased encephalic region, including left middle frontal gyrus (BA47), left inferior frontal gyrus (BA45), right middle frontal gyrus (BA10) and right inferior frontal gyrus (BA45, BA47). Compared to low blood glucose level group, prediabetes group had glucose metabolism decreased encephalic region, including left middle frontal gyrus (BA47), left inferior frontal gyrus (BA47, BA45, BA9) and right middle frontal gyrus (BA10). Conclusion There was glucose metabolism decreased in partial encephalic regions of prediabetic patients, which indicated abnormal cerebral metabolism can be observed in prediabetic stage. |
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