| 夏雷,全姬善,朴永男,孙玉今,李德奇,金光玉.超顺磁性氧化铁纳米粒子在肝癌诊断与治疗中的研究进展[J].中国医学影像技术,2016,32(7):1135~1138 |
| 超顺磁性氧化铁纳米粒子在肝癌诊断与治疗中的研究进展 |
| Research progresses of superparamagnetic iron oxide nanoparticles in diagnosis and treatment of liver cancer |
| 投稿时间：2015-11-25 修订日期：2016-04-01 |
| DOI：10.13929/j.1003-3289.2016.07.037 |
| 中文关键词: 肝肿瘤 磁共振成像 超顺磁性氧化铁纳米粒子 靶向传递 |
| 英文关键词:Liver neoplasms Magnetic resonance imaging Superparamagnetic iron oxide nanoparticles Targetting delivery |
| 基金项目:国家自然科学基金（81160176）、吉林省科技厅项目（20150101199JC） |
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| 中文摘要: |
| 超顺磁性氧化铁纳米粒子（SPION）作为MR负性对比剂被广泛认知，通过对其进行表面修饰，可明显提高其生物相容性与作用效果。利用外加磁场及交变电流，SPION还可具有靶向传递和磁热疗的作用。本文旨在对SPION在肝癌诊断和治疗方面的研究进展进行综述。 |
| 英文摘要: |
| Superparamagnetic iron oxide nanoparticles (SPION) has been known as MRI negative contrast agents. To improve its biocompatibility and effect of imaging, surface modification loading the ligand has been used to modificate the SPION. Targetting delivery and magnetic hyperthermia is allowed through the use of an external magnetic field and an alternating current. Research progresses of application of SPION on diagnosis and treatment of liver cancer were reviewed in this article. |
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