| 陈丽华,刘爱连,宋清伟,马春梅,汪禾清,张龙敏,佟梓滨.磁共振扩散峰度成像鉴别诊断前列腺癌与前列腺增生[J].中国医学影像技术,2016,32(7):1097~1101 |
| 磁共振扩散峰度成像鉴别诊断前列腺癌与前列腺增生 |
| Diffusion kurtosis imaging in differential diagnosis of prostate cancer and benign prostatic hyperplasia |
| 投稿时间：2015-10-05 修订日期：2016-01-26 |
| DOI：10.13929/j.1003-3289.2016.07.029 |
| 中文关键词: 前列腺肿瘤 前列腺增生 扩散峰度成像 扩散磁共振成像 |
| 英文关键词:Prostatic neoplasms Prostatic hyperplasia Diffusion kurtosis imaging Diffusion magnetic resonance imaging |
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| 中文摘要: |
| 目的 探讨磁共振扩散峰度成像（DKI）鉴别诊断前列腺癌（PCa）与前列腺增生（BPH）的应用价值。方法 回顾性分析前列腺疾病患者59例，根据病理结果分为PCa组和BPH组。对所有患者均行MR常规扫描和肝脏容积超快速三维成像序列动态增强扫描、DWI及DKI扫描。由2名医师测量两组病灶DKI的各参数值。采用组内相关系数（ICC）分析2名医师测量结果的一致性；对两组各参数值的比较采用两独立样本t检验；绘制各参数的ROC曲线，分析诊断效能。结果 2名观察者测得两组各参数值一致性良好（ICC均>0.75）。PCa组平均扩散峰度值、平行扩散峰度值、垂直扩散峰度值高于BPH组（P均<0.01）；PCa组平均扩散系数、平行扩散系数、垂直扩散系数值低于BPH组（P均<0.01）。ROC分析显示各参数诊断PCa和BPH的曲线下面积均>0.90。结论 DKI各参数可为临床鉴别诊断PCa和BPH提供更多重要的参考信息。 |
| 英文摘要: |
| Objective To evaluate the application value of diffusion kurtosis imaging (DKI) in differential diagnosis of prostatic carcinoma (PCa) and benign prostatic hyperplasia (BPH). Methods Fifty-nine patients with the suspicion of prostate disease were recruited, who were divided into PCa group and BPH group. All the patients were performed routine MRI, liver acquisition with volume acceleration sequence scan, DWI and DKI. The value of the parameters of DKI were measured by two experienced radiologist. Intraclass correlation coefficient (ICC) test was used to examine the consistency of the measurements, and student's t-test was executed to compare the parameters of both groups. The ROC curve of all the parameters were drew and analyzed. Results The consistency of all parameters in the PCa group and BPH group were higher (all ICC>0.75). The mean kurtosis, axial kurtosis, radial kurtosis of PCa group were significantly higher than those of BPH group (all P<0.01), while the mean diffusivity, axial diffusivity, radial diffusivity were significantly lower than those of BPH group (all P<0.01). The area under the ROC curve of all parameters were higher than 0.90. Conclusion The parameters of DKI can provide more important reference for differential diagnosis of PCa and BPH. |
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